Recombinant Bovine Cyclic AMP-responsive element-binding protein 1(CREB1)

Code CSB-YP005947BO
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Source Yeast
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Code CSB-EP005947BO
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Source E.coli
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Code CSB-EP005947BO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005947BO
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Source Baculovirus
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Code CSB-MP005947BO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CREB1
Uniprot No. P27925
Alternative Names CREB1; CREB; CREB2Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1; Cyclic AMP-responsive DNA-binding protein
Species Bos taurus (Bovine)
Expression Region 1-325
Target Protein Sequence MESGAENQQS GDAAVTEAES QQMTVQAQPQ IATLAQVSMP AAHATSSAPT VTLVQLPNGQ TVQVHGVIQA AQPSVIQSPQ VQTVQISTIA ESEDSQESVD SVTDSQKRRE ILSRRPSYRK ILNDLSSDAP GVPRIEEEKS EEETSAPAIT TVTVPTPIYQ TSSGQYIAIT QGGAIQLANN GTDGVQGLQT LTMTNAAATQ PGTTILQYAQ TTDGQQILVP SNQVVVQAAS GDVQTYQIRT APTSTIAPGV VMASSPALPT QPAEEAARKR EVRLMKNREA ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKSD
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Gene References into Functions
  1. Data indicate that Ser738/742-to-glutamate protein kinase D mutant increased AngII-induced CREB protein and activating transcription factor 2 phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein promoter. PMID: 24708239
  2. SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia. PMID: 12552083
  3. dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 PMID: 12810819
  4. the p38-MAPK/CREB pathway plays a critical role in TNFalpha-induced VCAM-1 expression PMID: 16715652
Subcellular Location Nucleus.
Protein Families BZIP family
Database Links

KEGG: bta:281713

STRING: 9913.ENSBTAP00000007201

UniGene: Bt.4183

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