Recombinant Cat Endothelin-1(EDN1)

Code CSB-YP692689CA
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Source Yeast
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Code CSB-EP692689CA
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Source E.coli
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Code CSB-EP692689CA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP692689CA
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Source Baculovirus
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Code CSB-MP692689CA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names EDN1
Uniprot No. Q5NRQ1
Alternative Names EDN1Endothelin-1; ET-1; Preproendothelin-1; PPET1) [Cleaved into: Big endothelin-1]
Species Felis catus (Cat) (Felis silvestris catus)
Expression Region 53-73
Target Protein Sequence CSCSSLLD KECVYFCHLD IIW
Protein Length Cytoplasmic domain
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells.
Gene References into Functions
  1. we propose that endogenous ET-1 mediates the hypertrophic response to Ang II by a mechanism that involves EGFR transactivation and redox-dependent activation...in adult cardiomyocytes PMID: 24327206
  2. IT was concluded that ET-1 may prove a useful diagnostic biomarker for asthma. PMID: 23750948
  3. Positive inotropic effect after exposure to 1 nmol/L Ang II is due to endogenous ET-1 acting through ETA receptor and triggering ROS production, Na+/H+ exchanger stimulation, and Na+/Ca2+ exchanger reverse mode activation. PMID: 16505203
  4. our data suggest that ET-1 causes p38 MAPK-dependent expression of COX-2 by interacting with ETB receptors on esophageal smooth muscle cells. PMID: 16951549
Subcellular Location Secreted.
Protein Families Endothelin/sarafotoxin family
Database Links

KEGG: fca:494214

STRING: 9685.ENSFCAP00000013767

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