EDN1

Endothelin-1 (EDN1) is a protein encoded by the EDN1 gene. Also known as ET-1, it is a potent vasoconstrictor peptide. EDN1 binds to endothelin receptors (ETA and ETB) on vascular smooth muscle cells, triggering calcium influx and subsequent muscle contraction. It is involved in the renin - angiotensin - aldosterone system and other signaling pathways related to vascular tone regulation.
EDN1 is associated with various diseases, such as pulmonary arterial hypertension and essential hypertension. In drug development, endothelin receptor antagonists like bosentan have been developed to block EDN1's actions, showing promise in treating related cardiovascular conditions and improving patient prognosis.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

EDN1 Antibody (CSB-PA004918)

Validated Data

Western Blot analysis of mouse lung cells using ET-1 Polyclonal Antibody

Human Endothelin 1,ET-1 ELISA Kit (CSB-E07007h)

Validated Data

Code: CSB-E07007h

Size: 96T,5×96T,10×96T

Sensitivity: 0.78 pg/mL

Detection Range: 3.12 pg/mL-200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following EDN1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

EDN1 Antibodies

EDN1 Proteins

EDN1 ELISA Kits

EDN1 Antibodies

EDN1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA007400GA01HU	EDN1 Antibody	Human	ELISA,WB,IHC
CSB-PA004918	EDN1 Antibody	Human	WB, ELISA
CSB-PA924161	EDN1 Antibody	Human	ELISA,IHC
CSB-PA784177	EDN1 Antibody	Human	ELISA,IHC
CSB-PA198612	EDN1 Antibody	Human	ELISA,IHC

EDN1 Antibodies for Rattus norvegicus (Rat)

Code	Product Name	Species Reactivity	Application
CSB-PA007400ZA01RA	Edn1 Antibody	Rattus norvegicus	ELISA, WB (ensure identification of antigen)

EDN1 Proteins

EDN1 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP007400GU CSB-EP007400GU CSB-BP007400GU CSB-MP007400GU CSB-EP007400GU-B	Recombinant Guinea pig Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP007400DO CSB-EP007400DO CSB-BP007400DO CSB-MP007400DO CSB-EP007400DO-B	Recombinant Dog Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP007400MO CSB-EP007400MO CSB-BP007400MO CSB-MP007400MO CSB-EP007400MO-B	Recombinant Mouse Endothelin-1 (Edn1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP007400BO CSB-EP007400BO CSB-BP007400BO CSB-MP007400BO CSB-EP007400BO-B	Recombinant Bovine Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP007400RB CSB-EP007400RB CSB-BP007400RB CSB-MP007400RB CSB-EP007400RB-B	Recombinant Rabbit Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP007400PI CSB-EP007400PI CSB-BP007400PI CSB-MP007400PI CSB-EP007400PI-B	Recombinant Pig Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-BP007400RA CSB-EP007400RA-B	Recombinant Rat Endothelin-1 (Edn1)	Baculovirus In Vivo Biotinylation in E.coli
CSB-EP007400RA	Recombinant Rat Endothelin-1 (Edn1), partial	E.coli
CSB-YP007400RA	Recombinant Rat Endothelin-1 (Edn1)	Yeast
CSB-MP007400RA	Recombinant Rat Endothelin-1 (Edn1), partial	Mammalian cell

EDN1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP007400HU CSB-EP007400HU CSB-BP007400HU CSB-MP007400HU CSB-EP007400HU-B	Recombinant Human Endothelin-1 (EDN1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP007400HU	Recombinant Human Endothelin-1 (EDN1), partial	E.coli

EDN1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP631714MOV CSB-EP631714MOV CSB-BP631714MOV CSB-MP631714MOV CSB-EP631714MOV-B	Recombinant Macaca fascicularis Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP692689CA CSB-EP692689CA CSB-BP692689CA CSB-MP692689CA CSB-EP692689CA-B	Recombinant Cat Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)

Code	Product Name	Source
CSB-YP702924ADAU CSB-EP702924ADAU CSB-BP702924ADAU CSB-MP702924ADAU CSB-EP702924ADAU-B	Recombinant Atelerix albiventris Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP858990SH CSB-EP858990SH CSB-BP858990SH CSB-MP858990SH CSB-EP858990SH-B	Recombinant Sheep Endothelin-1 (EDN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EDN1 ELISA Kit

EDN1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Sample Types	Sensitivity
CSB-E07002c	Dog Endothelin 1,ET-1 ELISA Kit	serum, plasma, tissue homogenates	0.78 pg/mL

EDN1 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E05145m	Mouse Endothelin 1,ET-1 ELISA Kit	serum, plasma, cell culture supernates	3.9 pg/mL

EDN1 ELISA Kit for Sus scrofa (Pig)

Code	Product Name	Sample Types	Sensitivity
CSB-E06806p	Pig endothelin 1,ET-1 ELISA Kit	serum, plasma, tissue homogenates	0.78 pg/mL

EDN1 ELISA Kit for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Sample Types	Sensitivity
CSB-E06951Rb	Rabbit Endothelin 1,ET-1 ELISA Kit	serum, plasma, tissue homogenates	1.56 pg/mL

EDN1 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E06979r	rat Endothelin 1,ET-1 ELISA Kit	serum, plasma, cell lysates, tissue homogenates	0.31 pg/mL

EDN1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E07007h	Human Endothelin 1,ET-1 ELISA Kit	serum, cell culture supernates, urine, saliva	0.78 pg/mL

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