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Recombinant Dog Nitric oxide synthase, inducible (NOS2), partial

Recombinant Dog Nitric oxide synthase, inducible (NOS2), partial

Code	CSB-YP015943DO
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP015943DO
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP015943DO-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP015943DO
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP015943DO
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

NOS2

Uniprot No.

O62699

Alternative Names

NOS2; Nitric oxide synthase; inducible; EC 1.14.13.39; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.

Gene References into Functions

Increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours. PMID: 28956485
demonstrate for the first time that PPS is a novel inhibitor of IL-1beta-induced iNOS, c-Jun, and HIF-1alpha mRNA upregulation and iNOS protein induction which may be beneficial for prevention and treatment OA PMID: 28472120
IL-17A gene transcription level was positively correlated with mRNA expression for iNOS and IFN-gamma PMID: 26590047
Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression. PMID: 26824356
A positive correlation was found between the number of iNOS cells in lymph nodes and interferon-gamma levels, and there was a negative correlation between parasites and iNOS cell densities both in lymph nodes and spleen. PMID: 25195062
results showed that the median expression of iNOS was higher in symptomatic dogs and oligosymptomatic dogs compared to non-infected dogs PMID: 21188604
Chronic non-ischaemic heart failure results in atrial oxidative stress and electrophysiologic abnormalities by depletion of tetrahydrobiopterin and uncoupling of NOS2. PMID: 21460065
Inflammatory cytokines and NO form INOS may be involved in intraneural inflammatory changes arising from mechanical compression PMID: 16022989
treatment with avocado/soybean unsaponifiables can reduce the development of early osteoarthritic cartilage and subchondral bone lesions. This effect appears to be mediated through the inhibition of inducible nitric oxide synthase and MMP-13 PMID: 19291317