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Recombinant Guinea pig Nitric oxide synthase, inducible (NOS2), partial

Recombinant Guinea pig Nitric oxide synthase, inducible (NOS2), partial

Code	CSB-YP015943GU
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP015943GU
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP015943GU-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP015943GU
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP015943GU
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

NOS2

Uniprot No.

O54705

Alternative Names

NOS2; NOSNitric oxide synthase; inducible; EC 1.14.13.39; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2

Species

Cavia porcellus (Guinea pig)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.

Gene References into Functions

The expression of iNOS participates in the pathogenesis of cochlear damage caused by acoustic trauma. PMID: 22687355
Our data demonstrate that both iNOS and nNOS represent sources for nitric oxide overproduction in ileal myenteric plexus during ischemia and reperfusion PMID: 23279126
Salvia miltiorrhiza injection had no effect on the expression of nNOS and eNOS, but could inhibit iNOS in choclea. PMID: 21845886
iNOS and AChE expression increases in spiral ganglia treated with streptomycin. Salvia miltiorrhiza injection reduces ototoxicity by reducing the levels of iNOS and AChE. PMID: 21189568
The auditory brainstem response threshold increases and the expression of iNOS strengthens in streptomycin ototoxicity. PMID: 21166178

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Subcellular Location

Cytoplasm, cytosol.

Protein Families

NOS family

Tissue Specificity

Expressed in the lung and colon. Not detected in the heart, aorta, liver, kidney, and spleen.

Database Links

STRING: 10141.ENSCPOP00000017277

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