Recombinant Human Angiogenin(ANG),partial

Code CSB-RP057294h
Product Type Recombinant Protein
Size US$1726
Uniprot No. P03950
Relevance Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Ribonuclease 5
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence DNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
Source E.coli
Gene Names ANG
Expression Region 26-147aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 18.0kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Involvement in disease Amyotrophic lateral sclerosis 9 (ALS9)
Subcellular Location Cytoplasmic vesicle, secretory vesicle lumen, Secreted, Nucleus, Nucleus, nucleolus
Protein Families Pancreatic ribonuclease family
Tissue Specificity Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Database Links

HGNC: 483

OMIM: 105850

KEGG: hsa:283

STRING: 9606.ENSP00000336762

UniGene: Hs.283749

Q&A and Customer Reviews

Q&A
Q:

I have a question “Has cat# CSB-RP057294h been assayed for activity?”

A:
Very nice to receive your inquiry.
We haven't tested the activity of this protein yet. Our protein is purified under mild conditions which should have activity in theory. We suggest you to purchase a small amount to have a try first.
Customer Reviews

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