Angiogenin (ANG), encoded by the ANG gene, is a secreted ribonuclease critical for angiogenesis. Common aliases include angiogenin precursor and ANG1. It acts via dual mechanisms: as an RNase, it cleaves tRNAs to produce tiRNAs that regulate translation; it also binds cell surface receptors to activate cascades driving endothelial cell proliferation and migration.
ANG intersects with PI3K/Akt and MAPK pathways to promote angiogenesis. Dysregulation links it to tumor progression (e.g., lung, breast cancers) by supporting neovascularization, and neurodegenerative disorders like ALS due to impaired neuronal RNA metabolism. Drug development includes RNase inhibitors for cancer therapy and modulators exploring neuroprotection in ALS.
Recombinant Human Angiogenin (ANG), partial (CSB-EP001703HU1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Validated Data
Western Blot analysis of 293T Hela 823 cells using ANG I Polyclonal Antibody
ANG Recombinant Monoclonal Antibody (CSB-RA001703MA1HU)
Validated Data
IHC image of CSB-RA001703MA1HU diluted at 1:50 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA001703MA1HU diluted at 1:50 and staining in paraffin-embedded rat liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA001703MA1HU diluted at 1:50 and staining in paraffin-embedded mouse liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.
Human Angiogenin,ANG ELISA Kit (CSB-E04498h)
Validated Data
Code: CSB-E04498h
Size: 96T,5×96T,10×96T
Sensitivity: 3.9 pg/mL
Detection Range: 15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following ANG reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ANG Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA05729A0Rb | ANG Antibody | Human | ELISA, IHC |
| CSB-PA001703GA01HU | ANG Antibody | Human | ELISA,WB,IHC |
| CSB-PA006105 | ANG Antibody | Human | WB, ELISA |
| CSB-PA071857 | ANG Antibody | Human | ELISA,WB |
| CSB-RA001703MA1HU | ANG Recombinant Monoclonal Antibody | Human, Mouse | ELISA, IHC |
ANG Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP001703HU CSB-EP001703HU CSB-BP001703HU CSB-MP001703HU CSB-EP001703HU-B |
Recombinant Human Angiogenin (ANG) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001703HU1 | Recombinant Human Angiogenin (ANG), partial | E.coli |
ANG ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04498h | Human Angiogenin,ANG ELISA Kit | serum, plasma, cell culture supernates, urine, tissue homogenates | 3.9 pg/mL |