Recombinant Human Annexin A2(ANXA2)

Code CSB-EP001840HUe0
Size US$2062
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names ANXA2
Uniprot No. P07355
Alternative Names Annexin A2; Annexin II; Annexin II; heavy chain; Annexin-2; ANX 2; ANX2; ANX2L4; ANXA2; ANXA2_HUMAN; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); Calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8 ; Chromobindin-8; Epididymis secretory protein Li 270; HEL S 270; LIP2; Lipocortin II; LPC2; LPC2D; p36; P36 protein ; PAP-IV; Placental anticoagulant protein IV; Protein I
Species Homo sapiens (Human)
Source E.coli
Expression Region 2-339aa
Target Protein Sequence STVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 65.5 kDa
Protein Length Full Length of Mature Protein
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9
Gene References into Functions
  1. Mechanistic studies revealed that FOXD2AS1 upregulated the expression of the miR206 target gene ANXA2 in hepatocellular carcinoma by acting as a miR206 sponge. PMID: 30272362
  2. study has localised AnxA2/S100A10 complexes to key anatomical locations in the placenta and suggests a role for this complex in amniotic epithelium, trophoblasts and syncytium, in addition to its well-known roles in endothelial cells PMID: 30143909
  3. Inhibition of ANXA2 will affect the expression of downstream targets and downstream signaling pathways, leading to the suppression of the malignant progression of tumors. PMID: 30355917
  4. our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein beta-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers. PMID: 29332450
  5. aptamer wh6 can block MM cell adhesion to ANXA2 and block the proliferation of MM cells induced by ANXA2 PMID: 29906496
  6. The results demonstrated that ANX2 and stromal tenascin C regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of pancreatic ductal adenocarcinoma. PMID: 29749431
  7. highly expressed in gastric cancer, related to tumor size, histological differentiation, lymph node metastasis PMID: 29097873
  8. models for annexin A2-mediated vesicle aggregation mechanisms. PMID: 29567212
  9. Our profiling data provided a rich source for further study of the molecular mechanisms of acquired drug resistance inneuroblastoma ( NB). Further study may determine the role of ANXA2 as a prognostic biomarker and a potential therapeutic target for patients with multidrug-resistant NB. PMID: 28814318
  10. These results suggested that increased ANXA2 and less expressed beta-catenin were correlated to adenomyosis-associated dysmenorrhea PMID: 28547742
  11. These data suggested that Annexin A2 induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 signaling, and provided an evidence that blockade of Annexin A2 could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs PMID: 28886730
  12. Results show that Anxa2-Tyr23 phosphorylation is necessary for proliferation, invasion, and metastasis of breast cancer cells in vitro and in vivo. Tyr23-phosphorylated Anxa2 binds to STAT3 and serves as a key regulator of STAT3 signaling. PMID: 28470457
  13. annexin A2 can potentially predict the development of pre-eclampsia. The low annexin A2 levels (<0.89 ng/ml) together with higher blood pressure and proteinuria constitute a higher risk to develop preeclampsia. PMID: 28501283
  14. Variants in the Annexin A2 (ANXA2) gene directly influence plasma LDL-C levels. PMID: 28456096
  15. this study showed that Annexin A2 inhibition suppresses proliferation and invasion in ovarian cancer via beta-catenin/EMT, proposing the potential role of Annexin A2 in the prevention and treatment of ovarian cancer PMID: 28440436
  16. FNDC3B and ANXA2 expression correlate negatively with patient survival in hepatocellular carcinoma PMID: 27385217
  17. UBAP2 formed a complex with Annexin A2 and promoted the degradation of Annexin A2 protein by ubiquitination, and then inhibited HCC progression. PMID: 27121050
  18. results indicate that ANXA2 plays an important role to enhance the malignant behaviors of Hepatocellular carcinoma cells, and the enhancement is closely based on its remodeling to cell structures PMID: 27060670
  19. Thus, tight regulation of AnxA2 function is an integral aspect of cellular homeostasis. The presence of AnxA2 in cancer cell-derived exosomes, as well as the potential regulation of exosomal AnxA2 by phosphorylation or other PTMs, are topics of great interes PMID: 28867585
  20. Restoration of miR-101 expression reversed chemoresistance of drug-resistant gastric cancer cells by inhibiting viability and enhancing apoptosis via targeting ANXA2. PMID: 28609840
  21. Annexin 2A (ANXA2) is over-expressed in Glioblastoma (GBM) and positively correlates with patient outcome. PMID: 27429043
  22. Results confirm that both circRNA expression and even ANXA2 expression could be used as biomarkers of RR-MS with good values of specificity and sensitivity. PMID: 28651352
  23. This study demonstrated that the expression level of AnxA2 was significantly higher in recurrent adamantinomatous craniopharyngioma compared with primary ones. AND AnxA2(+) adamantinomatous craniopharyngioma cells exhibited enhanced proliferation and migration ability compared with AnxA2(-) adamantinomatous craniopharyngioma cells. PMID: 27640198
  24. Cercvical cancer stem cells express annexin II, an HPV co-receptor. PMID: 27008711
  25. Annexin A2 (ANXA2) and prostate-specific antigen (PSA) proteins measured from biopsy tumour regions are unlikely to be good biomarkers for prediction of the clinical outcome of prostate cancer presenting with apparently localized disease. PMID: 29187477
  26. anti-ANXA2 antibodies play a role in thrombotic mechanisms leading to recurrent pregnancy loss and placental vascular disease PMID: 27631133
  27. results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored PMID: 28976984
  28. Findings indicate that Munc13-4 supports acute WPB exocytosis by tethering WPBs to the plasma membrane via AnxA2-S100A10. PMID: 28450451
  29. Detecting ANXA2 and ANXA4 expression may aid the evaluation of cervical carcinoma prognosis. PMID: 27402115
  30. our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 mRNA mediated by the SMN complex. PMID: 28258160
  31. The data data suggest that interactions between HIV-1 gp120 and A2 exist, though this interaction may be indirect. PMID: 27863502
  32. Exosome-associated Annexin II plays an important role in angiogenesis and breast cancer metastasis. PMID: 27760843
  33. ANXA2 stromal expression might play a key role in aggressive tumor phenotype associated with increased EMT CTCs release, however, other factors beyond ANXA2 are responsible for coagulation activation mediated by CTCs in breast cancer patients. PMID: 28476852
  34. annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa. PMID: 28283478
  35. Annexin A2 and HB-EGF are overexpressed and are being secreted into serum in Her-2 negative breast cancer patients. PMID: 27496793
  36. results indicate that ANXA2 facilitates PS-ASO trafficking from early to late endosomes where it may also contribute to PS-ASO release PMID: 27378781
  37. Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis PMID: 27451994
  38. Rack1 regulated P-Glycoprotein activity, which was necessary for adriamycin-induced P-Glycoprotein - mediated phosphorylation of Anxa2 and Erk1/2. PMID: 27754360
  39. The presence of vascular lesions in lupus nephritis (LN) appears to be associated with significant differences in the vascular expression of ANXA2. PMID: 26511441
  40. expression elevated in lung squamous cell carcinoma tissue PMID: 28178129
  41. annexin A2 but not follistatin is expressed in hepatocellular carcinoma PMID: 26189841
  42. Our results place ANXA2 at the apex of a regulatory cascade that determines glioblastoma mesenchymal transformation and validate aSICS as a general methodology to uncover regulators of cancer subtypes. PMID: 27667176
  43. Overexpression of ANXA2 is associated with colorectal cancer. PMID: 27468721
  44. Annexin A2, up-regulated by IL-6, promotes ligament ossification in ankylosing spondylitis patients. PMID: 27697640
  45. highly specific 30 kDa plant lectin could dissociate AnxA2 from endogenous lectin galectin-3 interaction at the cell surface. This dissociation could down-regulate Bcl-2 family proteins, cell proliferation, and migration simultaneously triggering cell apoptosis PMID: 26438086
  46. Data show that ONECUT2, IGF2BP1, and ANXA2 proteins were confirmed to be microRNA-9 (miR-9) targets and aberrantly upregulated in hepatocellular carcinoma (HCC). PMID: 26547929
  47. annexin A2 and S100A10 expressions are powerful predictors of serous ovarian cancer outcome. PMID: 26925708
  48. expression of ANXA2 is associated with tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma PMID: 26196246
  49. Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer. PMID: 26307676
  50. the role of Axna2 is instructive for understanding the development of RA, suppress the effect of Axna2 might provide a new potential measure for treatment of RA. PMID: 26963384
  51. Suggest that ANX A2 plays an important role in aggressive breast tumor growth by regulating proteolytic pathways in the tumor microenvironment. PMID: 26797420
  52. Establish FXa as a potentially important asthma mediator, stimulating airway smooth muscle function through actions requiring PAR-1 and annexin A2 and involving integrin coactivation. PMID: 26120939
  53. RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway. PMID: 26253946
  54. These data show that disruption of ANX2/p11 interaction results in reduced ALL cell adhesion to osteoblasts, increased ALL cell sensitization to chemotherapy, and suppression of ALL cell homing and engraftment. PMID: 26465153
  55. Expression levels of ANXA2 and HE4 were closely related to the malignant biological behavior of endometrial carcinoma PMID: 26362938
  56. Data from studies using proteomic/microarray methods suggest ANXA2 (not ANXA5) plays important role in packaging of microRNAs into extracellular vesicles; this process appears independent of microRNA sequence and dependent on calcium signaling. PMID: 26632510
  57. This study shows that ANXA2 and GAL3 deregulated expression was associated with an invasive phenotype in gastric cancer cell lines and may contribute to metastasis in gastric cancer patients. PMID: 25034653
  58. ANXA2 up-regulation might represent an acquired metastasis phenotype of hepatocellular carcinoma (HCC), help to screen out high-risk population for HCC, or more effectively treat a subset of postsurgical HCC patients positive for ANXA2 PMID: 26109000
  59. It is a factor regulating angiogenesis and invasion of malignant gliomas. PMID: 25697644
  60. Results show the transcriptional repression of ANXA2 by ERG in prostate epithelial cells plays a critical role in abrogating differentiation, promoting epithelial-mesenchymal transition, and in the inverse correlation of expression seen in prostate tumor. PMID: 25344575
  61. Our results suggest a novel function of Ebp1 as a binding protein and negative regulator of Anxa2. The functional association between Anxa2 and EBP1 may participate in regulating cancer cell proliferation and invasion, contributing to cancer progression. PMID: 25917452
  62. MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression PMID: 26272794
  63. Study points out the regulatory function of Anxa2 in RCC cell motility and provides a molecular-based mechanism of Anxa2 positivity in the progression of RCC. PMID: 25284003
  64. It was found that soluble ANXA2 concentration in serum samples from 42 lung cancer patients was significantly higher than that from 43 healthy individuals PMID: 25519022
  65. High Annexin II expression is associated with esophageal squamous cell carcinoma. PMID: 25605255
  66. The present meta-analysis results indicated that ANXA2 overexpression might be associated with poor outcomes in patients with malignant tumors. PMID: 25476478
  67. UBE3A may regulate the expression of annexin A2, resulting in promotion of proliferation and invasion and suppression of apoptosis in breast cancer cells. PMID: 25816213
  68. Annexin A2 complexes with S100 proteins: structure, function and pharmacological manipulation PMID: 25303710
  69. Annexin A2 is required for the early steps of cytokinesis to set up the RhoA signaling pathway at the cortical ring. PMID: 25712672
  70. Data show that VvpE elastase induces the hypomethylation of the interleukin 1 beta {IL-1beta) promoter and the transcriptional regulation of NF-kappaappaB through annexin A (ANXA)2 recruitment to promote IL-1beta production in intestinal epithelial cells. PMID: 26223656
  71. Mir206 targets ANXA2 and Kras genes in pancreatic adenocarcinoma. PMID: 25500542
  72. Data indicate that annexin A2 overexpression in microsatellite instability (MIN) cells induces disassembly and colocalization of coilin with centromeres. PMID: 25347736
  73. data suggest that Annexin A2 may play an important role in epithelial ovarian cancer (EOC) cell proliferation and may promote the progression of EOC PMID: 25547062
  74. Annexin A2 was identified as down-regulated in the esophageal squamous cell carcinoma tissues after 2-DE Gel coupled with MALDI-TOF-MS identification. PMID: 24668792
  75. CARDS toxin binds selectively to annexin A2; it serves as a distinct receptor for CARDS toxin binding and internalization and enhances CARDS toxin-induced vacuolization in mammalian cells PMID: 25139904
  76. Serum levels of ANXA2 may have a good diagnostic and predictive marker for response to chemotherapy in patients with gastric cancer and have not associated with prognosis. PMID: 25661364
  77. AnxA2 cellular localization was observed in cell clusters that define tumor budding, and a significant association between both variables was detected. PMID: 25795236
  78. These data indicate a novel functional role of AnxA2 in the negative post-transcriptional regulation of type I collagen synthesis in human fibroblasts. PMID: 25290763
  79. role in the mesothelial phagocytosis of crocidolite and may serve as its receptor PMID: 25915724
  80. ANXA2 mediates resistance to gemcitabine by directly increasing the activity of NF-kappaB. PMID: 25611381
  81. annexin A2 (ANXA2) on nasopharygeal carcinoma cells is a ligand for DC-SIGN on dendritic cells PMID: 25402728
  82. High expression of Annexin A2 is associated with pancreatic ductal adenocarcinoma. PMID: 25520129
  83. metastatic cancer cells have elevated rate of cell injury and they rely on the S100A11-ANXA2 complex to enable cell membrane repair. S100A11 in a complex with Annexin A2 helps reseal the plasma membrane. PMID: 24806074
  84. Consistently, double-labeling immunofluorescence experiments illustrated co-localization of ANXA2 and Lewis y antigen within the same area. In conclusions, ANXA2 contains Lewis y antigen. PMID: 25416440
  85. Results reveal that AnxA2 and its derivatives bind cooperatively to membranes containing cholesterol, phosphatidylserine, and/or phosphatidylinositol-4,5-bisphosphate, thus providing a mechanistic model for the lipid clustering activity of AnxA2 PMID: 25418092
  86. HE4 and annexin II binding interaction promoted ovarian cancer cell invasion. PMID: 25362534
  87. Data indicate that annexin A2 (ANXA2) SUMOylation is regulated by insulin. PMID: 25775977
  88. Data suggest that calcium-dependent phosphatidylinositol 4,5-diphosphate- (PI(4,5)P2-) binding proteins (such as ANXA2, PRKCA [protein kinase C alpha], and SYT1 [synaptotagmin I]) interactions with membrane microdomains are tightly regulated. [REVIEW] PMID: 25233429
  89. findings indicate a significant decrease in Anx A2 expression in colon cancer patients compared to healthy controls and in parallel with tumor progression PMID: 25287627
  90. Data suggest that S100A4 and Annexin A2 proteins could be useful prognostic markers to predict tumor progression and prognosis in urothelial carcinoma of the urinary bladder. PMID: 24968947
  91. Demonstrate increased placental Annexin A2 mRNA expression during the acute phase of preeclampsia. PMID: 25803884
  92. ANXA2 effectively predicted those endometrioid endometrial carcinomas that finally recurred. PMID: 25219463
  93. Urinary calreticulin, annexin A2, and annexin A3 are very likely a panel of biomarkers with potential value for upper tract urothelial carcinoma diagnosis. PMID: 24884814
  94. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. [Review] PMID: 24591759
  95. the present study demonstrated that ANXA2 and SOD2 are potential target genes of HOXA13 and their coexpression predicts the poor prognosis of Esophageal squamous cell carcinoma patients. PMID: 24626613
  96. annexin A2 may participate in keloid formation by inhibiting keloid fibroblast proliferation. PMID: 24402284
  97. Our results support a model whereby AnxA2 limits the availability of TRPA1 channels to regulate nociceptive signaling in vertebrates. PMID: 25355205
  98. Annexin A2 is a key molecule in the DDR-2/annexin A2/MMP-13 loop, the activation of which contributes to joint destruction in rheumatoid arthritis, mainly through promoting invasion of fibroblast-like synoviocytes. PMID: 24819400
  99. Authors show here that AnxA2, p11 and AHNAK are required for type 3 secretion system-mediated Salmonella invasion of cultured epithelial cells. PMID: 23931152
  100. data revealed a plausible new role of AnxA2 in the reduction of PCSK9 protein levels via a translational mechanism. PMID: 24808179

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Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane, Melanosome
Protein Families Annexin family
Database Links

HGNC: 537

OMIM: 151740

KEGG: hsa:302

STRING: 9606.ENSP00000346032

UniGene: Hs.511605

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