Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like(BNIP3L)

Code CSB-YP002767HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. O60238
Relevance Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP002767HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) BNIP3L.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP002767HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) BNIP3L.
Storage Buffer Tris-based buffer,50% glycerol
Alias Adenovirus E1B19K-binding protein B5 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A NIP3-like protein X Short name: NIP3L
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MSSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSASTY
Research Area Cancer
Source Yeast
Gene Names BNIP3L
Protein Names Recommended name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeAlternative name(s): Adenovirus E1B19K-binding protein B5 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A NIP3-like protein X Short name= NIP3L
Expression Region 1-219aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 25.9kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP
Subcellular Location Nucleus envelope, Endoplasmic reticulum, Mitochondrion outer membrane, Membrane, Single-pass membrane protein
Protein Families NIP3 family
Database Links

HGNC: 1085

OMIM: 605368

KEGG: hsa:665

STRING: 9606.ENSP00000370003

UniGene: Hs.131226

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