Recombinant Human Bone morphogenetic protein 1 (BMP1)

1. investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of coronary heart disease. PMID: 30062502
2. Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP-Smad1 signaling pathway. PMID: 28944874
3. For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations. PMID: 28365001
4. BMP1 c.941G>A (p.(R314H)) variant was identified in the family with Chiari malformation type 1. PMID: 28513615
5. Results indicate the significance of follistatin-like protein 1 (FSTL1) in driving oncogenesis and metastasis in esophageal squamous cell carcinoma (ESCC) by coordinating NF-kappa B (NFkappaB) and bone morphogenetic proteins (BMP) pathway control. PMID: 28883005
6. Given the association of BMP1-related Osteogenesis Imperfecta (OI) with very high bone material density, concerns remain whether anti-resorptive therapy is indicated in this ultra-rare form of OI PMID: 27576954
7. Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity. PMID: 27782377
8. a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 in the EGF domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications. PMID: 26944735
9. BMP-1 accelerates the connective tissue growth factor production dependently on cellular internalization in human dental pulp cells, indicating a novel property of BMP-1 which potentially enhances bone-like reparative dentin formation. PMID: 25944709
10. Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways. PMID: 26592459
11. study thus highlights the severe and progressive nature of BMP1-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM organization. PMID: 25656619
12. Data indicate that BMP-1 can simultaneously trigger matrix assembly and boost the synthesis of matrix proteins via a direct effect on growth factors in the contexts of development, growth and tissue repair. [review] PMID: 25701650
13. Two novel variants in the BMP1 gene: c.808A>G and c.1297G>T care associated with osteogenesis imperfecta. PMID: 25402547
14. Frequent bone fracture in children is cause by BMP1-1 deficiency. PMID: 25214535
15. mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency PMID: 25158199
16. High BMP1 expression is associated with type-1 diabetes. PMID: 24984282
17. Loss of bone morphogenetic protein is associated with prostate cancer. PMID: 24042462
18. miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1 PMID: 23584484
19. Sequence analysis of BMP1 genes did not reveal any putative mutations for hyperostosis cranialis interna to chromosome 8p21 PMID: 23640157
20. Controlling inhibition of bone morphogenetic protein (BMP1) modulates the number of SOX1 expressing cells, whereas PAX6, another neural precursor marker, remains the same. PMID: 22860217
21. Excluding anterior cervical fusions, there are no significant differences between spinal fusion procedures with and without BMP-associated overall complications. PMID: 21897187
22. The molecular and cellular bases of BMP1-dependent osteogenesis were defined. The importance of BMP1 for bone formation and stability were shown in humans and zebrafish. PMID: 22482805
23. We conclude that BMP1 is an additional gene mutated in autosomal recessive osteogenesis imperfecta (AR-OI). PMID: 22052668
24. High expression of BMP pathway genes are associated with atypical teratoid/rhabdoid tumors. PMID: 21946044
25. Disruption of BMPR1A-mediated BMP1 signalling during the narrow window of early embryogenesis may interfere with normal VBW formation, causing omphalocele phenotype in the Cd chick model. PMID: 21258932
26. Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. PMID: 21697095
27. BMP1-3 is a novel systemic regulator of bone repair. PMID: 21453682
28. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis. PMID: 21415150
29. Three isoforms of BMP1 ranging from the shortest BMP1-5 to the longest (mTLD, inefficient at processing procollagen in vitro) were all shown to be capable of removing the highly conserved propeptides from both proDCN. PMID: 20026052
30. Data show that only those containing both PCPE1 CUB1 and CUB2 were capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity. PMID: 19801683
31. bone morphogenetic protein-1 (BMP-1), which exhibits procollagen C-proteinase activity, cleaves the C-terminal propeptide from human procollagen VII PMID: 11986329
32. Post-translational modification is required for secretion and stability of the protein. PMID: 12218058
33. the minimal domain structure for PCP activity is considerably shorter than expected and comprises the metalloproteinase domain and the CUB1 and CUB2 domains of BMP-1 PMID: 12637537
34. Pro-BMP-1 is cleaved in the trans-Golgi network PMID: 12637569
35. Dermal wound healing in red Duroc pigs show unique mRNA expression of HSP47,BMP-1,TIMP1-3 and hypercontracted,hyperpigmented scars. PMID: 15225209
36. cleaves LG3 from recombinant endorepellin at the physiologically relevant site and cleaves LG3 from endogenous perlecan in cultured mouse and human cells PMID: 15591058
37. chordinase activity of BMP1 is not enhanced by PCPE-1 PMID: 15817489
38. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
39. bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin PMID: 17071617
40. the BMP1 prodomain specifically binds and regulates signaling by BMP2 and BMP4 PMID: 17255107
41. By mutating residues flanking the cleavage site of collagen type V alpha 1, we showed that the aspartate residue at position P2' is essential for BMP-1 activity. PMID: 17407447
42. data support the concept that the C-terminal domains of BMP1 are important for substrate recognition and for controlling and restricting its proteolytic activity via exosite binding PMID: 17516847
43. BMP1 processes PRL to a 17-kDa anti-angiogenic factor. PMID: 17548836
44. vascular Bmp Msx2 Wnt signaling and oxidative stress have roles in arterial calcification [review] PMID: 18056036
45. Expression of BMP1, BMP6, BMP7, and BMP-receptor 2 was significantly increased in advanced stages of myelofibrosis compared and enhanced levels of BMP6 expression were already evident in prefibrotic stages of primary myelofibrosis. PMID: 18349123
46. The crystal structures of the protease domains of human BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are reported. PMID: 18824173
47. BMP-1 expression was significantly higher in thyroid tumors with psammoma bodies or with stromal calcification. PMID: 19305382
48. Regulation of alternative splicing of mRNA for procollagen C-endopeptidase in leiomyomas and myometrium depends mainly on the hormonal status of women PMID: 19323056
49. FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases. PMID: 19617627

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HGNC: 1067

OMIM: 112264

KEGG: hsa:649

STRING: 9606.ENSP00000305714

UniGene: Hs.1274