Recombinant Human CCAAT/enhancer-binding protein delta (CEBPD)

1. gemcabene decreases CRP by C/EBP-delta and NF-kappaB-mediated transcriptional mechanism and suppresses IL-6 and IL-1beta-induced CRP production. PMID: 29644527
2. tudy underscores how CEBPD functions at the junction of inflammation and lipid accumulation in M1 macrophages PMID: 28859294
3. the EGFR/STAT3 pathway contributed to CDDP-induced CEBPD expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduced the expression of CEBPD and enhanced the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel PMID: 27435393
4. These findings demonstrate a critical function for the astrocytic CEBPD, and point to miR-135a antagonist as an attractive therapeutic target for the treatment of Alzheimer's disease. PMID: 26208701
5. These findings identify a molecular mechanism by which ERalpha signaling reduces the aggressiveness of cancer cells, and demonstrate that C/EBPdelta can have different functions in different types of cancer. PMID: 27181204
6. CREB overexpression increased CCAAT-enhancer-binding protein-delta (C/EBPdelta) levels to cause myeloid differentiation arrest, and the silencing of CREB-C/EBPdelta axis restored myeloid terminal differentiation PMID: 27118402
7. Data suggest that proinflammatory cytokine interleukin-1beta (IL1B) up-regulates hepcidin expression in hepatocytes; inflammation induces IL1B production in Kupffer cells and hepatocytes; IL1B up-regulates CEBPD (CCAAT/enhancer binding protein delta) expression in hepatocytes; up-regulation of CEBPD expression up-regulates hepcidin transcription. PMID: 28438835
8. the C/EBPD binding site is required for RU486-mediated activation of the CHOP promoter. PMID: 26174226
9. Results suggest that CCAAT/enhancer binding protein delta (CEBPD) could be a useful diagnostic marker and therapeutic target in hepatocellular carcinoma (HCC). PMID: 26358750
10. CEBPD amplification and overexpression is associated with urothelial carcinoma. PMID: 26307680
11. Knock-down of C/EBPdelta expression in pericytes following immune stimulation increased chemokine and adhesion molecule expression. PMID: 26166618
12. We have discovered the CEBPD-hypoxia-inducible factor-1 (HIF-1) pathway as a new HIF-1-regulating fundamental mechanism in tubular epithelial cells for the cellular protection against kidney injury. PMID: 25692954
13. Authors found that CK2 bound to C/EBPdelta, which might help to target CK2 to the transcriptional machinery where it can phosphorylate other transcription factors or co-activators. PMID: 25680545
14. Data indicate that dysfunction of the Rho-associated kinase 2 (Rock2)-p-GSK3beta/beta-catenin-CCAAT/enhancer-binding protein delta (CEBPD) regulatory circuitry may contribute to the tumorigenic characteristic of hepatocellular carcinoma (HCC). PMID: 25771860
15. GSK3beta-mediated CEBPD phosphorylation in astrocytes plays an important role in the activation of microglia. PMID: 23993701
16. the inflammatory PGE-HuR-C/EBPdelta axis in macrophages promotes tumor progression by preventing the phagocytosis of tumor cells and inducing immunosuppressive cytokine production. PMID: 23861541
17. CEBPD inhibits FBXW7 expression and augments HIF-1 alpha expression and activity under hypoxia PMID: 21076392
18. CEBPD supports inflammatory signaling through activation of the TLR4 gene; and is downregulated by FBXW7 alpha following phosphorylation by GSK-3 beta. PMID: 23575666
19. Review article on CEBPD expression, regulation and function with focus on inflammation and cancer. PMID: 24155666
20. The FRA8I fragile site includes KIAA0146, CEBPD and PRKDC and may have a role in colorectal cancer PMID: 23603433
21. Findings suggest that CEBPD and its downstream effectors could be biomarkers for the diagnosis of RA and potentially serve as therapeutic targets for RA therapy. PMID: 23028973
22. This study provides the first demonstration of a role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of AD pathogenesis. PMID: 21112127
23. Src kinase activity downregulates C/EBP-delta protein but not mRNA levels through a SIAH2 E3 ligase-dependent mechanism. PMID: 22037769
24. new function of CEBP-delta in lymphangiogenesis through regulation of VEGFR3 signaling in lymphatic endothelial cells PMID: 21666710
25. Data indicate that C/EBPdelta plays a role in late stages of keratinocyte differentiation. PMID: 21072181
26. HMDB kills cancer cells through activation of CEBPD pathways. PMID: 20971808
27. C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity. PMID: 20829351
28. Common allelic variants in CEBPD were not associated with obesity phenotypes in healthy White Northern European families. PMID: 20460359
29. found that C/EBPdelta promotes monoubiquitination of the Fanconi anemia complementation group D2 protein (FANCD2), which is necessary for its function in replication-associated DNA repair PMID: 20805509
30. C/EBPdelta expression may prevent the development of recurrences by inhibition of neoplastic growth in meningiomas PMID: 19806320
31. Expression of CEBPD reduces cisplatin-induced reactive oxygen species and apoptosis in NTUB1 carcinoma cells by inducing the expression of copper/zinc-superoxide dismutase via direct promoter transactivation. PMID: 20385105
32. These results suggest a potentially crucial role for NF-kappaB in the IL-1-induced expression of C/EBPdelta, and thereby downstream acute phase protein genes regulated by this transcription factor. PMID: 19800021
33. A single nucleotide polymorphism in the CEBPD gene was found in 2.9% of patients studied. PMID: 11851384
34. posttranscriptional and posttranslational regulation in G0 growth-arrested mammary epithelial cells PMID: 12554732
35. Expression levels of C/EBPdelta in breast tumors were correlated with clinicopathological tumor parameters, expression of estrogen and progesterone receptors (ER, PR), Ki67 immunostaining, and expression of 7 cell-cycle regulatory proteins. PMID: 12825852
36. C/EBPdelta has a role in abolishing CBP phosphorylation as well as transcriptional activation and could be important in C/EBP-mediated transcription PMID: 12857754
37. AD tissue sections revealed profuse C/EBPdelta staining of astrocytes, particularly reactive astrocytes surrounding amyloid beta peptide deposits. Substantially less immunoreactivity was observed in comparable sections from controls. PMID: 15212823
38. results indicate that the C/EBPdelta gene is controlled at multiple levels, consistent with a role for C/EBPdelta in cell cycle control and/or cell fate determination. PMID: 15389878
39. results demonstrate that "loss of function" alterations in the pSTAT3/C/EBPdelta growth inhibitory signal transduction pathway are relatively common in breast cancer cell lines PMID: 15389879
40. C EBP delta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. PMID: 15486993
41. Expression of C/EBPdelta in BCR-ABL-positive leukemic cells in blast crisis is sufficient for neutrophil differentiation. PMID: 15674331
42. IL-6 increases hepatic PAI-1 expression mediated by the -232- to -210-bp region of the promoter containing a C/EBPdelta binding site. PMID: 15718495
43. the PI3-kinase/p38(MAPK)/CREB pathway contributes to the EGF activation of NF-IL6beta gene expression PMID: 15901830
44. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, strengthening the role of C/EBPdelta in COX-2 gene transcription. PMID: 16195339
45. Reduced C/EBPdelta gene expression is associated with breast tumors PMID: 16322893
46. IL-1 and IL-6 exert directionally similar effects on PAI-1 expression, but the induction involves distinct signaling pathways with a final common mediator, C/EBPdelta. PMID: 16914534
47. Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis. PMID: 16997058
48. C/EBPdelta is a novel tumor suppressor gene in acute myeloid leukemia that is silenced by promoter methylation. PMID: 17234736
49. C/EBPdelta ubiquitination is not required for proteasome-mediated C/EBPdelta degradation and the presence of ubiquitin does not increase C/EBPdelta degradation by the proteasome. PMID: 17373909
50. C/EBPdelta, but not DeltaNp63alpha, indefinitely promotes holoclone self-renewal and prevents clonal evolution, suggesting that self-renewal and proliferation are distinct, albeit related, processes in limbal stem cells. PMID: 17562792

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HGNC: 1835

OMIM: 116898

KEGG: hsa:1052

STRING: 9606.ENSP00000386165

UniGene: Hs.440829