Recombinant Human Cardiotrophin-1 (CTF1)

1. Data suggest that, in children with pediatric obesity, lifestyle weight-loss intervention results in down-regulation of serum cardiotrophin-1 (CTF1), interleukin-6 (IL6), and tumor necrosis factor-alpha (TNFA); expression of CTF1, IL6, and TNFA is also down-regulated in peripheral blood mononuclear cells after improvement in adiposity, body mass index, and waist-hip ratio. PMID: 28749076
2. Cardiotrophin-1 levels were not an independent predictor of all-cause mortality in hemodialysis patients. PMID: 26787685
3. We identify the cytokine cardiotrophin 1 (CT1) as a factor capable of recapitulating the key features of physiologic growth of the heart including transient and reversible hypertrophy of the myocardium, and stimulation of cardiomyocyte-derived angiogenic signals leading to increased vascularity PMID: 28785017
4. a transcriptional factor, Myc-associated zinc finger protein (MAZ), plays an important role in ADAM10 transcription in response to CT-1 in neural stem/progenitor cells. PMID: 26867947
5. CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage. PMID: 26334851
6. non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels. PMID: 26621340
7. This paper will review many aspects of CT-1 physiological role in several organs and discuss data for consideration in therapeutic approaches. PMID: 26188636
8. biliary epithelium-derived CT-1 may exert a profibrogenic potential in PCLD. PMID: 25919795
9. Data show that cardiotrophin-1 is positively related to brachial-ankle pulse-wave velocity (baPWV) independent of traditional cardiometabolic risk factors for arterial stiffness. PMID: 25689900
10. this study, even though preliminary and awaiting further confirmation by independent replication, provides first evidence that common genetic variation in CTF1 could contribute to insulin sensitivity in humans. PMID: 25025664
11. Study correlates CT-1 levels with ambulatory and central BP, as well as with pulse wave velocity in patients with essential hypertension. PMID: 24401751
12. CT-1 is differentially induced in the myocardium of infants with congenital cardiac defects depending on hypoxemia, and may mediate myocardial hypertrophy and dysfunction. PMID: 24344663
13. Subjects with impaired glucose tolerance (IGT) and newly diagnosed diabetes (NDD) have significantly higher CT-1 concentrations than those with normal glucose tolerance. IGT and NDD are positively associated with CT-1 concentrations. PMID: 24054317
14. exaggerated cardiomyocyte production of cardiotrophin-1 in response to increased left ventricular end-diastolic stress may contribute to fibrosis through stimulation of fibroblasts in heart failure of hypertensive origin. PMID: 24366078
15. A reduction in serum CT-1 levels after a WL program. PMID: 23856329
16. CT-1 induces the proteolytic potential in human aortic endothelial cells by upregulating MMP-1 expression. PMID: 23935888
17. Cardiotrophin-1 may serve as both a biomarker of left ventricular hypertrophy and dysfunction in hypertensive patients, and is potential target for therapies aimed to prevent and treat hypertensive heart disease beyond blood pressure control. PMID: 22418690
18. Hypoxia increased cardiotrophin-1 levels in cardiac cells through a direct regulation of CT-1 promoter by HIF-1alpha, protecting cells from apoptosis. PMID: 21771897
19. CT-1 treatment of myofibroblasts was associated with increased phosphorylation of myosin light chain kinase via myosin light chain kinase to induce cell migration. PMID: 21572008
20. the 1742(C/G) polymorphism of the human CT-1 gene is associated with LVH in hypertension, and the GG genotype may have a protective role PMID: 20683337
21. This study aims to analyse cardiotrophin-1 (CT-1) and Tumor Necrosis Factor-alpha (TNF-alpha) plasma levels at rest and during exercise in elite athletes and healthy controls. PMID: 20053569
22. Data show that both protein synthesis and intracellular transport are essential for cardiotrophin-1 induced TNFalpha expression. PMID: 20224758
23. upregulation of cardiotrophin-1 in congestive heart failure PMID: 12234945
24. Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor PMID: 12707269
25. Our study clearly demonstrates production of CT-1 in the postnatal and adult CNS, specifically by cell types comprising the blood-CSF barrier, and its accumulation in ventricular ependyma. PMID: 15219667
26. Data show that cardiotrophin (CT-1) is a potent regulator of signaling in adipocytes in vitro and in vivo. PMID: 15339920
27. CT-1 and TGF-beta 1 exert differential effects on myofibroblast proliferation and contraction in vitro. A balance of these effects may be important for normal cardiac wound healing. PMID: 17483238
28. adipose tissue can be recognized as a source of CT-1, which could account for the high circulating levels of CT-1 in patients with metabolic syndrome X PMID: 17940213
29. Increased expression of some IL-6 cytokine family members (oncostatin M, gp130, CT-1, LIF) in cutaneous inflammation might contribute to the promotion of hair loss. PMID: 17979974
30. Perioperative plasma brain natriuretic peptide and cardiotrophin-1 measured in off-pump coronary artery bypass. PMID: 18609050
31. Plasma cardiotrophin-1 is associated with progression of heart failure in hypertensive patients. PMID: 19155793
32. Results indicate that transcription factors such as CTF1 can act to delimit chromatin domain boundaries at mammalian telomeres, thereby blocking the propagation of a silent chromatin structure. PMID: 19273604

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HGNC: 2499

OMIM: 600435

KEGG: hsa:1489

STRING: 9606.ENSP00000279804

UniGene: Hs.483811