Recombinant Human Cathepsin F protein (CTSF), partial

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Code CSB-RP152794h
Size $224
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP152794h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CTSF.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP152794h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CTSF.
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Product Details

Greater than 90% as determined by SDS-PAGE.
Target Names
Uniprot No.
Research Area
Alternative Names
AI481912; CATF_HUMAN; Cathepsin F; CathepsinF; CATSF; CLN13; Ctsf; EC
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
Protein Length
Tag Info
N-terminal 6xHis-tagged
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

Amino acids 273-484 form the expressed segment for recombinant Human CTSF. The calculated molecular weight for this CTSF protein is 27.4 kDa. This CTSF protein is produced using e.coli expression system. The N-terminal 6xHis tag was fused into the coding gene segment of CTSF, making it easier to detect and purify the CTSF recombinant protein in the later stages of expression and purification.

The human cathepsin F protein (CTSF), belonging to the papain family of cysteine proteases, is a lysosomal cysteine protease involved in the degradation of proteins within lysosomes. CTSF is primarily localized in lysosomes, where it participates in the processing and turnover of intracellular proteins. It exhibits endopeptidase activity, cleaving peptide bonds within proteins and peptides. Research on CTSF encompasses its role in cellular proteolysis, antigen presentation, and immune responses. Understanding the function of CTSF contributes to insights into lysosomal biology, protein degradation pathways, and its potential implications in diseases associated with lysosomal dysfunction.

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Target Background

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Gene References into Functions
  1. The CTSF gene may function as a tumor suppressor in gastric cancer PMID: 28474574
  2. Biallelic mutations in this gene have been shown to cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis with some cases resembling the impairment seen in AD. PMID: 27524508
  3. Disease-causing cathepsin-F mutants fail to cleave LIMP-2. Our findings provide evidence that LIMP-2 represents an in vivo substrate of cathepsin-F with relevance for understanding the pathophysiology of type-B-Kufs-disease. PMID: 25576872
  4. Small hairpin RNA silencing of proteinases overexpressed in diabetic corneas enhanced corneal epithelial and stem cell marker staining and accelerated wound healing. PMID: 24255036
  5. Homozygous and compound heterozygous missense mutations in CTSF are associated with adult-onset neuronal ceroid lipofuscinosis. PMID: 23297359
  6. cathepsin F has a role in modifying low density lipoprotein particles PMID: 15184381
  7. cathepsin F, matrix metalloproteinases 11 and 12 are upregulated in cervical cancer PMID: 15989693
  8. data demonstrate a novel proatherogenic role for AngII, namely its ability to enhance secretion of lysosomal cathepsin F by monocyte-derived macrophages PMID: 16963053

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Involvement in disease
Ceroid lipofuscinosis, neuronal, 13 (CLN13)
Subcellular Location
Protein Families
Peptidase C1 family
Tissue Specificity
High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus.
Database Links

HGNC: 2531

OMIM: 603539

KEGG: hsa:8722

STRING: 9606.ENSP00000310832

UniGene: Hs.11590

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