Recombinant Human Chromodomain-helicase-DNA-binding protein 1 (CHD1), partial

1. CHD1 loss is associated with an increased sensitivity to PARP inhibition and anti-cancer drugs that induce DNA intercross-strand links in prostate tumors. PMID: 28383660
2. Increased CHD1L protein expression was significantly associated with poor overall survival in pancreatic cancer patients. PMID: 28646284
3. CHD1 facilitates substrate handover from XPC to the downstream TFIIH (transcription factor IIH). PMID: 29018037
4. CHD1 is required for the induction of osteoblast-specific gene expression, extracellular-matrix mineralization and ectopic bone formation in vivo. Genome-wide occupancy analyses revealed increased CHD1 occupancy around the transcriptional start site of differentiation-activated genes. PMID: 28475736
5. examined the role of CHD1 in DNA double-strand break (DSB) repair in prostate cancer cells; findings show that CHD1 is required for the recruitment of CtIP to chromatin and subsequent end resection during DNA DSB repair; data support a role for CHD1 in opening the chromatin around the DSB to facilitate the recruitment of homologous recombination (HR) proteins PMID: 27596623
6. In PTEN-deficient prostate and breast cancers, CHD1 depletion profoundly and specifically suppressed cell proliferation, cell survival and tumorigenic potential. PMID: 28166537
7. The authors have identified an additional conserved domain C-terminal to the SANT-SLIDE domain and determined its structure by multidimensional heteronuclear NMR spectroscopy. They have termed this domain the CHD1 helical C-terminal (CHCT) domain as it is comprised of five alpha-helices arranged in a variant helical bundle topology. PMID: 27591891
8. These results indicate that CHD1 is a positive regulator of influenza virus multiplication and suggest a role for chromatin remodeling in the control of the influenza virus life cycle. PMID: 26792750
9. These data link the assembly of methylated KDM1A and CHD1 with AR-dependent transcription and genomic translocations, thereby providing mechanistic insight into the formation of TMPRSS2-ERG gene fusions during prostate-tumor evolution. PMID: 26751641
10. The double chromodomains of CHD1 adopt an 'open pocket' to interact with the free N-terminal amine of H3K4, and the open pocket permits the NS1 mimic to bind in a distinct conformation. PMID: 24853335
11. identify coordinate loss of MAP3K7 and CHD1 as a unique driver of aggressive prostate cancer development PMID: 25770290
12. CHD1 and CHD2 act as positive regulators of HIV-1 gene expression. PMID: 25297984
13. results demonstrate the ability of confocal microscopy and FISH to identify the cell-to-cell differences in common gene fusions such as TMPRSS2-ERG that may arise independently within the same tumor focus PMID: 25175909
14. Data indicate that chromodomain-helicase-DNA-binding protein CHD1, neoplasm protein GREB1 and karyopherin alpha 2 protein KPNA2 as critical mediators of miR-26a and miR-26b elicited cell growth. PMID: 24735615
15. CHD1 is the 5q21 tumor suppressor gene in prostate cancer PMID: 23492366
16. findings suggest that CHD1 deletion may underlie cell invasiveness in a subset of prostate cancers, and indicate a possible novel role of altered chromatin remodeling in prostate tumorigenesis PMID: 22179824
17. findings collectively suggest that distinct CHD1-associated alterations of genomic structure evolve during and are required for the development of prostate cancer PMID: 22139082
18. CHD1, was the most "dietary sensitive" genes, as methylation of their promoters was associated with intakes of at least two out of the eight dietary methyl factors examined. PMID: 22048254
19. that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells PMID: 22046413
20. Mediator coactivator complex, which controls PIC assembly, is also necessary for CHD1 recruitment PMID: 21979373
21. associates with NCoR and histone deacetylase as well as with RNA splicing proteins PMID: 12890497
22. yeast and human CHD1 have diverged in their ability to discriminate covalently modified histones and link histone modification-recognition and non-covalent chromatin remodeling activities within a single human protein PMID: 16263726
23. the structure of the tandem arrangement of the human CHD1 chromodomains, and its interactions with histone tails PMID: 16372014
24. analysis of chromodomains in human and fungal Chd1 PMID: 17098252
25. overexpression of CHD1L could sustain tumor cell survival by preventing Nur77-mediated apoptosis PMID: 19441106

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HGNC: 1915

OMIM: 602118

KEGG: hsa:1105

STRING: 9606.ENSP00000284049

UniGene: Hs.643465