Recombinant Human Delta-type opioid receptor (OPRD1), partial

1. During prolonged hypoxia/ischemia delta-opioid receptor (DOR) neuroprotection involves a variety of signaling pathways. The data suggest that DOR may display its neuroprotective role via the BDNF-TrkB pathway. [review] PMID: 29768254
2. Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human delta-opioid receptor turnover at the plasma membrane. PMID: 29097258
3. OPRD1 gene variants and their haplotypes can play important roles in susceptibility to opioid dependence. PMID: 28632076
4. Homozygotes AA at rs6265 (BDNF), TT at rs16917234 (BDNF), and CC at rs508448 (OPRD1) also appeared as risk factors for the endophenotype earlier age of onset for heroin use. PMID: 28692418
5. Di-lysine binding motifs within the second and third intracellular loops of DOPr are involved in the interaction with COPI. PMID: 28041939
6. Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK) cells stably transfected with one of KOP, MOP or DOP PMID: 28049031
7. A polymorphism in OPRD1 appears to be associated with both cocaine dependence and cocaine use during treatment in African-Americans. Follow-up studies to confirm the effect on cocaine use are warranted. PMID: 27449273
8. OPRD1 promoter hypermethylation is associated with the risk of AD PMID: 28253273
9. This review addresses Delta Opioid receptors from the perspective of cellular and molecular determinants of their pharmacological diversity. PMID: 27343248
10. After inhibition of the PKC/ERK signalling pathway, the effects of DOR on breast cancer were significantly attenuated in vivo and in vitro. In summary, DOR is highly expressed in breast cancer and is closely related to its progression. These results suggest that DOR may serve as a potential biomarker for the early diagnosis of breast cancer and may be a viable molecular target for therapeutic intervention. PMID: 27665747
11. The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1, OPRK1, OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone. PMID: 26946441
12. the expression of DOR was upregulated in the drugresistant human hepatocellular carcinoma cells. PMID: 26549838
13. OPRD-mediated activation of ERK1/2 is via ligand-specific transactivation of EGFR. PMID: 26211551
14. Results suggest deltaOR-Phe27Cys variation modulates beta- and gamma-secretase activity in late-stage Alzheimer's disease likely via post-translational mechanisms PMID: 26402014
15. findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS severity. PMID: 26233486
16. Activation of the delta opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration PMID: 24628261
17. Analysis of the transcription factor POU2F3 revealed a DOPr-mediated extracellular signal-regulated kinase (ERK)-dependent downregulation of this factorThe delta-opioid receptor affects epidermal homeostasis PMID: 25178105
18. findings suggest that rs581111 and rs52920 may be useful when considering treatment options for female opioid addicts, however, confirmation in an independent sample is warranted PMID: 24126707
19. OPRD1 rs678849 polymorphism was associated with reduced brain volumes in young participants and elderly Alzheimer's Disease and Mild Cognitive Impairment patients, but brain regions affected differed PMID: 23427138
20. Taken together, the hdeltaOR appears to rely primarily on the CNX-mediated N-glycan-dependent QC that has the capacity to assist in folding PMID: 24798333
21. OPRD1 polymorphisms are associated with risk for heroin dependence. PMID: 22500942
22. Some variants less known for obesity-susceptibility such as OPRD1 were found to be associated to weight with strongest effects in males. PMID: 23318717
23. DOR is highly expressed in HCC and is involved in HCC progression, suggesting that DOR is a potential target for HCC treatment PMID: 23903826
24. crystal structure of the human delta-opioid receptor (delta-OR), revealing the presence and fundamental role of a sodium ion in mediating allosteric control of receptor functional selectivity and constitutive activity PMID: 24413399
25. The levels of spontaneous and ligand-induced receptor-G protein coupling in delta (DOP) and mu (MOP) opioid receptors, was examined. PMID: 23836900
26. Polymorphisms in OPRD1 are relevant for cocaine addiction in the African American population and support a broad role for OPRD1 variants in drug dependence. PMID: 22795689
27. delta and mu-opioid receptors, but not kappa-opioid receptors, are functional in the neuronally stimulated longitudinal human vas deferens PMID: 22752269
28. SNPs rs569356 in OPRD1 (variant A1968G in the promoter region) was not associated with respiratory syncytial virus infection PMID: 23222260
29. no differences in DOR mRNA levels were seen in schizophrenia. PMID: 21810780
30. between CBR and delta opioid receptor PMID: 22235275
31. ssarrestin1 is exclusively involved in human delta-opioid receptor desensitization PMID: 22101011
32. Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. PMID: 22184124
33. study confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 confer risk for AN. PMID: 21079607
34. suggest that aging individuals with at least one human delta opioid receptor(hdeltaOR)(Cys27) encoding allele might have lowered threshold for Ca(2)+ dysregulation in neurons expressing hdeltaOR PMID: 21234650
35. Data suggest that muOR exists primarily as a dimer that will oligomerize with deltaOR into tetramers, and morphine promotes the dissociation of these tetramers. PMID: 21361347
36. data suggest that an increased constitutive internalization and/or concurrent signaling of the delta-opioid receptor-Cys27 variant affects APP processing through altered endocytic trafficking of APP PMID: 21464208
37. Results suggest that the minor G-allele of SNP rs569356 may enhance transcription factor binding and increase OPRD1 expression. PMID: 20300121
38. human delta opioid receptor (hdeltaOR) exists in a ternary complex with SERCA2b and the ER molecular chaperone calnexin PMID: 20528919
39. A molecular mechanism for the formation of a DOR/secretase complex that regulates the specificity of secretase for Amyloid beta production. PMID: 20066010
40. Intrinsic cardiac adrenergic cells constitute a delta-opioid-regulated adrenopeptidergic paracrine system conferring robust cardioprotection through beta(2)-AR/CGRP-R co-signalling. PMID: 19581316
41. These results suggest that oligomerization of chemokine receptor CCR5 and opioid receptors mu, delta and kappa on the cell membrane of human or monkey lymphocytes may modulate receptor functions. PMID: 12413885
42. Gene may be linked to etiology of anorexia nervosa. PMID: 12740597
43. random mutagenesis identified 30 activating point mutations. 3-D modeling revealed an activation path originating from the third extracellular loop and propagating through tightly packed helices III, VI and VII down to a VI-VII cytoplasmic switch. PMID: 12847517
44. protein conformation and binding site for deltorphin ii PMID: 14999000
45. interaction studies between the delta-opioid receptor, ligands, and G-proteins PMID: 15317820
46. investigation of the ability of different opioid receptors to regulate the phosphorylation and degradation of tuberin PMID: 16053916
47. Results describe the residues of the transmembrane helices 7 of delta and kappa opioid receptors that are on the water-accessible surface of the binding-site crevices. PMID: 16331961
48. Results suggest that the OPRD1 gene variants may not be a factor in vulnerability to methamphetamine dependence/psychosis. PMID: 16741914
49. Changes in the inhibitory effects of opioid receptor agonists on intracellular cAMP were used as a marker of the function delta opioid receptors (delta receptor). PMID: 16808998
50. pharmacological chaperones facilitate plasma membrane targeting of delta-opioid receptors by binding and stabilizing receptor precursors, thereby promoting their release from the stringent ER quality control PMID: 17550902

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HGNC: 8153

OMIM: 165195

KEGG: hsa:4985

STRING: 9606.ENSP00000234961

UniGene: Hs.372