OPRD1 Antibody

Code CSB-RA947666A0HU
Size US$350Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western Blot
    Positive WB detected in: SH-SY5Y whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, U251 whole cell lysate, A549 whole cell lysate, Mouse brain tissue
    All lanes: OPRD1 antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 41 kDa
    Observed band size: 41 kDa
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Product Details

Uniprot No. P41143
Target Names OPRD1
Alternative Names Delta-type opioid receptor (D-OR-1) (DOR-1), OPRD1, OPRD
Species Reactivity Human, Mouse
Immunogen A synthesized peptide derived from human OPRD1
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Clone No. 7G7
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Gene References into Functions
  1. During prolonged hypoxia/ischemia delta-opioid receptor (DOR) neuroprotection involves a variety of signaling pathways. The data suggest that DOR may display its neuroprotective role via the BDNF-TrkB pathway. [review] PMID: 29768254
  2. Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human delta-opioid receptor turnover at the plasma membrane. PMID: 29097258
  3. OPRD1 gene variants and their haplotypes can play important roles in susceptibility to opioid dependence. PMID: 28632076
  4. Homozygotes AA at rs6265 (BDNF), TT at rs16917234 (BDNF), and CC at rs508448 (OPRD1) also appeared as risk factors for the endophenotype earlier age of onset for heroin use. PMID: 28692418
  5. Di-lysine binding motifs within the second and third intracellular loops of DOPr are involved in the interaction with COPI. PMID: 28041939
  6. Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK) cells stably transfected with one of KOP, MOP or DOP PMID: 28049031
  7. A polymorphism in OPRD1 appears to be associated with both cocaine dependence and cocaine use during treatment in African-Americans. Follow-up studies to confirm the effect on cocaine use are warranted. PMID: 27449273
  8. OPRD1 promoter hypermethylation is associated with the risk of AD PMID: 28253273
  9. This review addresses Delta Opioid receptors from the perspective of cellular and molecular determinants of their pharmacological diversity. PMID: 27343248
  10. After inhibition of the PKC/ERK signalling pathway, the effects of DOR on breast cancer were significantly attenuated in vivo and in vitro. In summary, DOR is highly expressed in breast cancer and is closely related to its progression. These results suggest that DOR may serve as a potential biomarker for the early diagnosis of breast cancer and may be a viable molecular target for therapeutic intervention. PMID: 27665747
  11. The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1, OPRK1, OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone. PMID: 26946441
  12. the expression of DOR was upregulated in the drugresistant human hepatocellular carcinoma cells. PMID: 26549838
  13. OPRD-mediated activation of ERK1/2 is via ligand-specific transactivation of EGFR. PMID: 26211551
  14. Results suggest deltaOR-Phe27Cys variation modulates beta- and gamma-secretase activity in late-stage Alzheimer's disease likely via post-translational mechanisms PMID: 26402014
  15. findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS severity. PMID: 26233486
  16. Activation of the delta opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration PMID: 24628261
  17. Analysis of the transcription factor POU2F3 revealed a DOPr-mediated extracellular signal-regulated kinase (ERK)-dependent downregulation of this factorThe delta-opioid receptor affects epidermal homeostasis PMID: 25178105
  18. findings suggest that rs581111 and rs52920 may be useful when considering treatment options for female opioid addicts, however, confirmation in an independent sample is warranted PMID: 24126707
  19. OPRD1 rs678849 polymorphism was associated with reduced brain volumes in young participants and elderly Alzheimer's Disease and Mild Cognitive Impairment patients, but brain regions affected differed PMID: 23427138
  20. Taken together, the hdeltaOR appears to rely primarily on the CNX-mediated N-glycan-dependent QC that has the capacity to assist in folding PMID: 24798333
  21. OPRD1 polymorphisms are associated with risk for heroin dependence. PMID: 22500942
  22. Some variants less known for obesity-susceptibility such as OPRD1 were found to be associated to weight with strongest effects in males. PMID: 23318717
  23. DOR is highly expressed in HCC and is involved in HCC progression, suggesting that DOR is a potential target for HCC treatment PMID: 23903826
  24. crystal structure of the human delta-opioid receptor (delta-OR), revealing the presence and fundamental role of a sodium ion in mediating allosteric control of receptor functional selectivity and constitutive activity PMID: 24413399
  25. The levels of spontaneous and ligand-induced receptor-G protein coupling in delta (DOP) and mu (MOP) opioid receptors, was examined. PMID: 23836900
  26. Polymorphisms in OPRD1 are relevant for cocaine addiction in the African American population and support a broad role for OPRD1 variants in drug dependence. PMID: 22795689
  27. delta and mu-opioid receptors, but not kappa-opioid receptors, are functional in the neuronally stimulated longitudinal human vas deferens PMID: 22752269
  28. SNPs rs569356 in OPRD1 (variant A1968G in the promoter region) was not associated with respiratory syncytial virus infection PMID: 23222260
  29. no differences in DOR mRNA levels were seen in schizophrenia. PMID: 21810780
  30. between CBR and delta opioid receptor PMID: 22235275
  31. ssarrestin1 is exclusively involved in human delta-opioid receptor desensitization PMID: 22101011
  32. Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. PMID: 22184124
  33. study confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 confer risk for AN. PMID: 21079607
  34. suggest that aging individuals with at least one human delta opioid receptor(hdeltaOR)(Cys27) encoding allele might have lowered threshold for Ca(2)+ dysregulation in neurons expressing hdeltaOR PMID: 21234650
  35. Data suggest that muOR exists primarily as a dimer that will oligomerize with deltaOR into tetramers, and morphine promotes the dissociation of these tetramers. PMID: 21361347
  36. data suggest that an increased constitutive internalization and/or concurrent signaling of the delta-opioid receptor-Cys27 variant affects APP processing through altered endocytic trafficking of APP PMID: 21464208
  37. Results suggest that the minor G-allele of SNP rs569356 may enhance transcription factor binding and increase OPRD1 expression. PMID: 20300121
  38. human delta opioid receptor (hdeltaOR) exists in a ternary complex with SERCA2b and the ER molecular chaperone calnexin PMID: 20528919
  39. A molecular mechanism for the formation of a DOR/secretase complex that regulates the specificity of secretase for Amyloid beta production. PMID: 20066010
  40. Intrinsic cardiac adrenergic cells constitute a delta-opioid-regulated adrenopeptidergic paracrine system conferring robust cardioprotection through beta(2)-AR/CGRP-R co-signalling. PMID: 19581316
  41. These results suggest that oligomerization of chemokine receptor CCR5 and opioid receptors mu, delta and kappa on the cell membrane of human or monkey lymphocytes may modulate receptor functions. PMID: 12413885
  42. Gene may be linked to etiology of anorexia nervosa. PMID: 12740597
  43. random mutagenesis identified 30 activating point mutations. 3-D modeling revealed an activation path originating from the third extracellular loop and propagating through tightly packed helices III, VI and VII down to a VI-VII cytoplasmic switch. PMID: 12847517
  44. protein conformation and binding site for deltorphin ii PMID: 14999000
  45. interaction studies between the delta-opioid receptor, ligands, and G-proteins PMID: 15317820
  46. investigation of the ability of different opioid receptors to regulate the phosphorylation and degradation of tuberin PMID: 16053916
  47. Results describe the residues of the transmembrane helices 7 of delta and kappa opioid receptors that are on the water-accessible surface of the binding-site crevices. PMID: 16331961
  48. Results suggest that the OPRD1 gene variants may not be a factor in vulnerability to methamphetamine dependence/psychosis. PMID: 16741914
  49. Changes in the inhibitory effects of opioid receptor agonists on intracellular cAMP were used as a marker of the function delta opioid receptors (delta receptor). PMID: 16808998
  50. pharmacological chaperones facilitate plasma membrane targeting of delta-opioid receptors by binding and stabilizing receptor precursors, thereby promoting their release from the stringent ER quality control PMID: 17550902

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
Database Links

HGNC: 8153

OMIM: 165195

KEGG: hsa:4985

STRING: 9606.ENSP00000234961

UniGene: Hs.372

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