Recombinant Human Draxin (DRAXIN)

Code CSB-YP822750HU
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Source Yeast
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Code CSB-EP822750HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP822750HU
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Source Baculovirus
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Code CSB-MP822750HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
DRAXIN
Uniprot No.
Alternative Names
AGPA3119; Chromosome 1 open reading frame 187 ; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; DRAXI_HUMAN; Draxin; FLJ34999; MGC117222; Neucrin; OTTHUMP00000002262; UNQ3119
Species
Homo sapiens (Human)
Expression Region
26-349
Target Protein Sequence
GALAP GTPARNLPEN HIDLPGPALW TPQASHHRRR GPGKKEWGPG LPSQAQDGAV VTATRQASRL PEAEGLLPEQ SPAGLLQDKD LLLGLALPYP EKENRPPGWE RTRKRSREHK RRRDRLRLHQ GRALVRGPSS LMKKAELSEA QVLDAAMEES STSLAPTMFF LTTFEAAPAT EESLILPVTS LRPQQAQPRS DGEVMPTLDM ALFDWTDYED LKPDGWPSAK KKEKHRGKLS SDGNETSPAE GEPCDHHQDC LPGTCCDLRE HLCTPHNRGL NNKCFDDCMC VEGLRCYAKF HRNRRVTRRK GRCVEPETAN GDQGSFINV
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Gene References into Functions
  1. results suggest that draxin functions as a repulsive guidance cue for PCN migration. However, we observed no significant differences in PCN distribution between draxin(-/-) and wild type embryos. PMID: 24832731
  2. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues. PMID: 19857465
Subcellular Location
Secreted.
Protein Families
Draxin family
Database Links

HGNC: 25054

OMIM: 612682

KEGG: hsa:374946

STRING: 9606.ENSP00000294485

UniGene: Hs.632364

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