Recombinant Human E3 ubiquitin-protein ligase NEDD4 (NEDD4), partial

1. NEDD4 mediates the EGFR lung cancer cell migration signaling through promoting lysosomal secretion of cathepsin B. PMID: 29455656
2. Data indicate the mechanism for epigenetic regulation in cancer by inducing E3 ubiquitin ligase NEDD4-dependent histone H3 ubiquitination. PMID: 28300060
3. We further investigated whether curcumin exerts its antitumor activities via suppressing NEDD4 expression. We found that curcumin reduced the expression of NEDD4 and Notch1 and pAKT, leading to glioma cell growth inhibition, apoptosis, and suppression of migration and invasion. Moreover, deletion of NEDD4 expression enhanced the sensitivity of glioma cells to curcumin treatment PMID: 28627598
4. an oncogenic E3 ubiquitin ligase promotes loss of gap junctions and Cx43 degradation in human carcinoma cells. PMID: 28733455
5. NEDD4 exerts its oncogenic function partly due to regulation of PTEN and Notch-1 in bladder cancer cells. PMID: 28745938
6. In the present study, we identified that the adaptor protein Numb, which is demonstrated to be a novel binding partner of NEDD4-1, plays important roles in controlling PTEN ubiquitination through regulating NEDD4-1 activity and the association between PTEN and NEDD4-1. PMID: 28437168
7. NEDD4 is an autophagic E3 ubiquitin ligase that ubiquitylates SQSTM1, facilitating SQSTM1-mediated inclusion body autophagy. PMID: 29021346
8. NEDD4 is largely involved in epithelial-mesenchymal transition features and chemoresistance of nasopharyngeal carcinoma cancer cells. PMID: 28379054
9. NEDD4 ligase regulates RTP801 and is sensitive to Parkinson disease-associated oxidative stress PMID: 27494837
10. Two additional regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes: the E3 ubiquitin ligases NEDD4 and MARCH8, are reported. PMID: 28320822
11. SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity. PMID: 28085563
12. Our results reveal a novel mechanism of upregulation of NEDD4 expression in pancreatic adenocarcinoma PMID: 28423617
13. Describe an autoinhibitory mechanism for NEDD4-1 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation. PMID: 28475870
14. Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity. PMID: 28470758
15. NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1. Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 are identified by NMR titration experiments. PMID: 28666866
16. Our results demonstrate that NEDD4 may promote the acquired resistance of non-small-cell lung cancer cells to erlotinib by decreasing phosphatase and tensin homolog deleted on chromosome 10 protein expression. Targeted decrease in NEDD4 expression may be a potential therapeutic strategy for tyrosine kinase inhibitor-resistant non-small-cell lung cancer. PMID: 28714370
17. this is the first demonstration that Nedd4-1 regulates hOAT1 ubiquitination, expression, and transport activity through its WW2 and WW3 domains PMID: 27226107
18. both Nedd4-1 and Nedd4-2 are important regulators for hOAT1 ubiquitination, expression, and function PMID: 26823285
19. Nedd4-1 inhibited Rap2a activity, and promoted the migration and invasion of glioma cells. PMID: 28405688
20. We concluded that USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination. PMID: 28126338
21. Data suggest a possible molecular mechanism might be that NEDD4 silence led to an increase in PTEN (phosphatase and tensin homologue) expression. PMID: 27467187
22. we found that Ndfipl binds to Nedd4-1, and that increased expression of Ndfipl significantly reduced Itch expression. We also found that increased ubiquitination played a role in Ndfipl-mediated processes, and that Ndfipl and a-synuclein interact PMID: 27173227
23. Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2. PMID: 26904956
24. Elevated NEDD4 is implicated as the responsible ubiquitin E3 ligase for HSF1 degradation through ubiquitin-proteasome system. Aberrant HSF1 degradation is a key neurodegenerative mechanism underlying alpha-synucleinopathy. PMID: 26503960
25. LRAD3 is a component of pathways that function effectively to modulate Itch and Nedd4 auto-ubiquitination and levels. PMID: 26854353
26. These results show that the binding of the hNedd4-1 WW3* domain to alpha-hENaC is coupled to the folding equilibrium PMID: 26685112
27. Data show that human ABCB1 is a substrate for human NEDD4-1 and identified 8 lysine residues that were ubiquitinated by NEDD4-1. PMID: 26006083
28. we demonstrate that the E3 ubiquitin ligase NEDD4 ubiquitinates IFITM3 in cells and in vitro. PMID: 26263374
29. Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR) through NEDD4 ubiquitin protein ligase and PTEN protein. PMID: 25883222
30. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. PMID: 25879670
31. NEDD4 controls the Hippo pathway leading to coordinated cell proliferation and apoptosis PMID: 25692647
32. sNEDD4 is a novel metastasis-associated gene, which prevents apoptosis under nutrient restriction conditions. This support the prognostic potential of sNEDD4 for Hepatocellular carcinoma. PMID: 25823820
33. Study identifies NEDD4 as a putative oncogene in endometrial cancer that may augment activation of the IGF-1R/PI3K/Akt signaling pathway. PMID: 26193427
34. HUWE1 and NEDD4-1 are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 and ABCG4 protein levels and cellular cholesterol export activity PMID: 26296893
35. Studies on Smurf2 and Nedd4 show that the C2 domain has the potential to regulate E3 activity by maintaining the HECT domain in a low-activity state where its ability for transthiolation and noncovalent Ubiquitin binding are impaired. PMID: 25438670
36. rs3088077, rs7162435 and rs2303579 of the NEDD4 gene are associated with schizophrenia. PMID: 26037357
37. Nedd4 promoted autophagy and was associated with the mTOR signalling pathway in the prostate cancer cells. PMID: 25809873
38. Nedd4-1 is an exceptional prognostic biomarker for GCA. PMID: 25395181
39. Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity. PMID: 25292214
40. NEDD4-1 overexpression sensitizes cancer cells to etoposide-induced apoptosis by reducing SAG levels through targeted degradation. SAG is added to a growing list of NEDD4-1 substrates and mediates its biological function. PMID: 25216516
41. Data show that NEDD4-1 E3 ligase as a novel component of the tumor suppressor protein p53/proto-oncogene proteins c-mdm2 regulatory feedback loop that controls p53 activity during stress responses. PMID: 24413081
42. Results demonstrated that NEDD4 is a novel interaction partner of HER3 and the C-terminal tail of HER3 interacts with the WW domains of NEDD4. PMID: 24662824
43. NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. [Review] PMID: 25527121
44. Findings suggest that the NEDD4-PTEN pathway is dysregulated in myotonic dystrophy type 2 skeletal muscle. PMID: 24907641
45. Findings revealed the CKI/SCF(beta-TRCP) signaling axis as the upstream negative regulator of NEDD4. PMID: 24657926
46. Relevant interaction partners of GUCD1 were identified, direct interactions with NEDD4-1 (E3 ubiquitin protein ligase neural precursor cell expressed, developmentally downregulated gene 4) was revealed, the latest resulted in control of GUCD1 stability. PMID: 24743017
47. Nedd4-1 as a general E3 ubiquitin ligase controls the abundance of all the three major forms of Ras, revealing a fundamental role of Nedd4-1 in regulating Ras signaling. PMID: 24746824
48. Lys-63 ubiquitination by Nedd4-1 facilitates endosomal targeting of alpha-synuclein. PMID: 24831002
49. NEDD4-1 regulates cell migration and invasion through ubiquitination of CNrasGEF in vitro. PMID: 24340059
50. NEDD4 directly interacts with LATS1, leading to ubiquitination and decreased levels of LATS1 and, thus, increased YAP localization in the nucleus, which subsequently increases the transcriptional activity of YAP. PMID: 24107629

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HGNC: 7727

OMIM: 602278

KEGG: hsa:4734

STRING: 9606.ENSP00000345530

UniGene: Hs.1565