Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

ELAVL3

Uniprot No.

Q14576

Research Area

Developmental Biology

Alternative Names

ELAV (embryonic lethal, abnormal vision, Drosophila) like 3 (Hu antigen C); ELAV (embryonic lethal, abnormal vision, Drosophila) like 4 (Hu antigen D); ELAV like 3; ELAV like 4; ELAV like neuron specific RNA binding protein 3; ELAV like neuron specific RNA binding protein 4; ELAV like protein 3; ELAV like protein 4; ELAV-like protein 3; ELAV3_HUMAN; Elavl3; ELAVL4; Hu antigen C; Hu antigen D; Hu-antigen C; HuC; HUCL; HuD; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic encephalomyelitis antigen HuD; Paraneoplastic limbic encephalitis antigen 21; PLE21; PNEM

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-367aa

Target Protein Sequence

MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

41.5kDa

Protein Length

Full Length

Tag Info

N-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The expression region of this recombinant Human ELAVL3 covers amino acids 1-367. This ELAVL3 protein is theoretically predicted to have a molecular weight of 41.5 kDa. This protein is generated in a yeast-based system. The ELAVL3 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant ELAVL3 protein during the following stages.

Human ELAV-like protein 3 (ELAVL3), a member of the ELAVL protein family, binds to RNA molecules and influences their processing, stability, and translation. ELAVL3 is predominantly expressed in neurons, highlighting its role in neuronal development and function. It is involved in the regulation of RNA metabolism in the nervous system. ELAVL3 participates in the regulation of alternative splicing, influencing the diversity of mRNA isoforms produced in neurons. This activity can impact protein diversity and function. ELAVL3 has been implicated in neuronal differentiation and maintenance of the neuronal phenotype. Its expression is often associated with developing and mature neurons. Dysregulation of ELAVL3 has been linked to neurodevelopmental disorders and neurological diseases, making them potential targets for therapeutic interventions.

Target Background

Function

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Plays a role in the stabilization of GAP43 mRNA and in spatial learning.

Gene References into Functions

HuC expression in neuroblastoma PMID: 12209604

Protein Families

RRM elav family

Tissue Specificity

Brain specific.

Database Links

HGNC: 3314

OMIM: 603458

KEGG: hsa:1995

STRING: 9606.ENSP00000352162

UniGene: Hs.1701

Code	CSB-YP618895HU
Abbreviation	Recombinant Human ELAVL3 protein
MSDS	MSDS Datasheet
Size	$250
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human ELAV-like protein 3 (ELAVL3)

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