Recombinant Human FGFR1 oncogene partner 2 (FGFR1OP2)

Code CSB-YP008644HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP008644HU
MSDS
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Source E.coli
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Code CSB-EP008644HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP008644HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP008644HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FGFR1OP2
Uniprot No.
Alternative Names
DKFZp564O1863; FGFR1 oncogene partner 2; FGFR1OP2; FGOP2_HUMAN; Fibroblast growth factor receptor 1 oncogene partner 2; HSPC123; HSPC123 like; WIT3.0; Wound inducible transcript 3.0
Species
Homo sapiens (Human)
Expression Region
1-253
Target Protein Sequence
MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALNKRV EAMKQYQEEI QELNEVARHR PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI MSKYREQMFR LLMASKKDDP GIIMKLKEQH SKIDMVHRNK SEGFFLDASR HILEAPQHGL ERRHLEANQN ELQAHVDQIT EMAAVMRKAI EIDEQQGCKE QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS ALVTNSDLSL RKS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May be involved in wound healing pathway.
Gene References into Functions
  1. The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulous mandible whereas the patients with that of rs840869 are not associated in Korean population. PMID: 22880093
  2. patients with the minor allele of rs840869 or rs859024 of FGFR1OP2 were associated with excessive atrophy of edentulous mandible PMID: 21283824
  3. FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure. PMID: 19959814
  4. FGFR1OP2 is a new FGFR1 fusion gene involving a chromosomes 12X8 translocation in a 8p11 myeloproliferative syndrome patient. PMID: 15034873
Involvement in disease
A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Subcellular Location
Cytoplasm.
Protein Families
SIKE family
Tissue Specificity
Expressed in bone marrow, spleen and thymus.
Database Links

HGNC: 23098

OMIM: 608858

KEGG: hsa:26127

STRING: 9606.ENSP00000229395

UniGene: Hs.591162

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