Recombinant Human Glutathione peroxidase 2(GPX2)(U40S)

Code CSB-YP009867HU
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Source Yeast
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Code CSB-EP009867HU
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Source E.coli
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Code CSB-EP009867HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009867HU
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Source Baculovirus
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Code CSB-MP009867HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names GPX2
Uniprot No. P18283
Alternative Names Gastrointestinal glutathione peroxidase; GI GPx; Glutathione peroxidase 2 (gastrointestinal); Glutathione peroxidase 2; Glutathione peroxidase gastrointestinal; Glutathione peroxidase related protein 2; Glutathione peroxidase-gastrointestinal; Glutathione peroxidase-related protein 2; GPRP; GPRP-2; GPx 2; GPx-2; GPx-GI; GPX2; GPX2_HUMAN; GSHPx 2; GSHPx GI; GSHPx-2; GSHPx-GI
Species Homo sapiens (Human)
Expression Region 1-190(U40S)
Target Protein Sequence MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLS GTTTRDFTQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
Gene References into Functions
  1. GPx2 may play an important role in the development of nasopharyngeal carcinoma. Furthermore, GPx2 may serve as a prognostic biomarker for NPC patient. PMID: 28453466
  2. Yes associated protein 1 (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 in a manner related to tumor protein p63 blockade. PMID: 28916653
  3. Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues. PMID: 27388201
  4. Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease PMID: 28631563
  5. glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients. PMID: 28635398
  6. Cardamonin exposure and selenium availability regulate expression of HO-1, GPX2 and TrxR1 in human intestinal cells. PMID: 26698667
  7. GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs. PMID: 25813210
  8. high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer. PMID: 25261240
  9. Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression. PMID: 24562575
  10. miR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression. PMID: 23934683
  11. A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
  12. A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency. PMID: 22758632
  13. Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue PMID: 11811519
  14. Data suggest that some antioxidants may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx by Nrf2 binding. PMID: 15923610
  15. some isoforms of p63 serve as a pro-survival factor by up-regulating GPX2 to reduce the p53-dependent oxidative stress-induced apoptotic response PMID: 16446369
  16. Glutathione peroxidase 2 (GPX2) is the major oxidative stress-inducible cellular GPX isoform in the lungs, and its basal as well as inducible expression is dependent on Nrf2. PMID: 16794261
  17. SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with Barrett's esophagus or esophageal adenocarcinoma PMID: 17277236
  18. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. PMID: 17937616
  19. Gpx2 is an overexpressed gene in human breast cancers PMID: 18056462
  20. Results show that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 and mPGES-1 expression. PMID: 18479189
  21. No significant risk for GPX2 in colorectal adenoma. PMID: 18483336
  22. Data show that GPx2 inhibits malignant characteristics of tumor cells, migration and invasion, obviously by counteracting COX-2 expression but is required for the growth of transformed intestinal cells and may, therefore, facilitate tumor cell growth. PMID: 19047153
  23. Knockout studies in mice suggest that Gpx2 mRNA and GPX-2 activity levels are induced by luminal microflora, consistent with a role in suppression of inflammation in the mucosal epithelium during weaning. PMID: 12751789

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Subcellular Location Cytoplasm
Protein Families Glutathione peroxidase family
Tissue Specificity Mostly in liver and gastrointestinal tract, not found in heart or kidney.
Database Links

HGNC: 4554

OMIM: 138319

KEGG: hsa:2877

STRING: 9606.ENSP00000374265

UniGene: Hs.2704

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