Code | CSB-RP150894h |
MSDS | |
Size | $224 |
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The recombinant Human HLA-B protein is encoded by the gene of HLA-B (25-308aa). The gene of HLA-B was cloned in a system (E.coli) that supported the expression of HLA-B. Modification of HLA-B by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis tag in the production. The purity is 90% determined by SDS-PAGE.
HLA-B is a protein coding gene that encodes HLA-B protein. According to some studies, HLA-B may have the following features.
The dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Genetic variation in the HLA-B region and hypersensitivity to abacavir. The innate partnership of HLA-B and KIR3DL1 subtypes to HIV-1. Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. A clone of a member of the immunoglobulin superfamily related to the recognition of HLA-C and HLA-B by human natural killer cells. The apparent interaction between KIR3DS1 and HLA-B delayed the development of AIDS. The assembly and maturation of HLA-A and HLA-B antigens in vivo. Reactivity of the Bw4 common epitope of the HLA-B molecule with natural killer cell clones expressing NKB1, a putative HLA receptor.
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We are trying to develop a multiplexing assay on Luminex to detect the HLA Class I and II antibodies in individuals.
We are looking for manufacturer who can provide us human derived recombined HLA class I and II antigens, checked on your website and find some Locus antigens are available with you. For the panel designing we need antigens of locu B.
Could you please provide some idea about it?
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