HLA-B

The gene HLA-B encodes the protein HLA-B molecule, also known as major histocompatibility complex class I, B. This protein plays a crucial role in the immune system by presenting antigens to T-cells, facilitating the recognition and elimination of infected or abnormal cells. HLA-B is highly polymorphic, with numerous variants that can influence immune responses and susceptibility to diseases. It is involved in various immune pathways, including those associated with infectious diseases and autoimmune disorders. The study of HLA-B has led to advancements in drug development, particularly in the field of pharmacogenomics, where HLA-B genotyping is used to predict adverse drug reactions and optimize treatment strategies.