Recombinant Human HLA class II histocompatibility antigen, DO beta chain(HLA-DOB),partial

Code CSB-YP318411HU
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Source Yeast
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Code CSB-EP318411HU
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Source E.coli
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Code CSB-EP318411HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP318411HU
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Source Baculovirus
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Code CSB-MP318411HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names HLA-DOB
Uniprot No. P13765
Alternative Names HLA-DOBHLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
Gene References into Functions
  1. results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence PMID: 28813660
  2. HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9. PMID: 23400868
  3. HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
  4. A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing. PMID: 15730525
Subcellular Location Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Protein Families MHC class II family
Database Links

HGNC: 4937

OMIM: 142920

KEGG: hsa:3112

STRING: 9606.ENSP00000390020

UniGene: Hs.1802

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Address
7505 Fannin St. Ste 610-312, Houston, TX 77054, USA
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