HLA-DOB Antibody

Code CSB-PA002935
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western Blot analysis of 293 cells using HLA-DOβ Polyclonal Antibody
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Product Details

Uniprot No. P13765
Target Names HLA-DOB
Alternative Names HLA-DOBHLA class II histocompatibility antigen antibody; DO beta chain antibody; MHC class II antigen DOB antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the N-terminal region of Human HLA-DOβ.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
Gene References into Functions
  1. results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence PMID: 28813660
  2. HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9. PMID: 23400868
  3. HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
  4. A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing. PMID: 15730525
Subcellular Location Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Protein Families MHC class II family
Database Links

HGNC: 4937

OMIM: 142920

KEGG: hsa:3112

STRING: 9606.ENSP00000390020

UniGene: Hs.1802

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