Recombinant Human Homeobox protein Hox-B2 (HOXB2)

Code CSB-YP010662HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP010662HU
MSDS
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Source E.coli
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Code CSB-EP010662HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP010662HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP010662HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
HOXB2
Uniprot No.
Alternative Names
homeo box 2H; homeo box B2; homeobox B2; Homeobox protein Hox-2.8; Homeobox protein Hox-2H; Homeobox protein Hox-B2; Hox 2 8 ; Hox 2H; HOX2 ; HOX2H ; hoxb2; HXB2_HUMAN; K8; K8 home protein
Species
Homo sapiens (Human)
Expression Region
1-356
Target Protein Sequence
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE QTFPSLQPGA STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE KKSAKKPSQS ATSPSPAASA VPASGVGSPA DGLGLPEAGG GGARRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA AWEACCHPPE VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA IDLQFP
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. HOXB2 and HOXB3 act as tumor suppressors in acute myeloid leukemia patients carrying the FLT3 protein mutations. PMID: 26482852
  2. Increased expression of HOXB2 protein is associated with HPV infection and cervical cancer progression. PMID: 25743797
  3. HOXB2 acts as a negative tumor growth regulator, decreasing proliferation in mammary adenocarcinoma tumors. PMID: 21672623
  4. hoxb2 and hoxb4 expression is related to erythroid hematopoiesis, and hoxb4 has greater relevance to erythroid hematopoiesis as compared with hoxb2. PMID: 20030938
  5. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
  6. Hoxb2 is a direct target for regulation by PLZF in the developing CNS and suggest that deregulation of Hox gene expression may contribute to APL pathogenesis. PMID: 12802276
  7. HOXB2 up-regulated lesions to have much higher HOXB2 expression than the corresponding normal tissue. PMID: 17805056

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family, Proboscipedia subfamily
Database Links

HGNC: 5113

OMIM: 142967

KEGG: hsa:3212

STRING: 9606.ENSP00000331741

UniGene: Hs.514289

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