Recombinant Human Importin subunit alpha-5 (KPNA1)

1. Importin alpha1 is specifically required for the nuclear localization of several important HSV1 proteins, capsid assembly, and capsid egress into the cytoplasm, and may become rate limiting in situ upon infection at low multiplicity or in terminally differentiated cells such as neurons. PMID: 29304174
2. Karyoppherins constitute integral constituents of the nuclear pore complex whose barrier, transport, and cargo release functionalities establish a continuum under a mechanism of Kap-centric control. PMID: 28864541
3. Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1/2 induced by IFN-beta, but p-STAT1/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 and induces degradation of cellular KPNA1 via caspase-3. [EV17 = Enterovirus 71] PMID: 28455446
4. Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with TPX2 protein. PMID: 26414402
5. BIG3 may block the KPNAs (KPNA1, KPNA5, and KPNA6) binding region(s) of PHB2. PMID: 26052702
6. miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy PMID: 24284509
7. Bel1 fragment with residues 215-223, which bears the NLS, interacts with KPNA1, KPNA6, and KPNA7. PMID: 25272585
8. Results indicate CTNNBL1 as a unique selective nuclear localization signals (NLSs)-binding protein with striking differences from karyopherin-alphas. PMID: 24269683
9. This supports the notion that de novo mutations KPNA1 in are extremely rare in schizophrenia PMID: 23425335
10. LRRC59 facilitates transport of cytosolic FGF1 through nuclear pores by interaction with Kpns and movement of LRRC59 along the ER and NE membranes PMID: 22321063
11. mTOR and protein phosphatase 2A catalytically control the constitutive nuclear import of latent STAT1 by KPNA1, which are key modulators of STAT1 expression and apoptosis. PMID: 22399302
12. the requirement for and the regulation of CAS in the functioning of the Vpr-Impalpha complex PMID: 22110766
13. Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin alpha5. PMID: 22130666
14. The ability of hnRNP C1/C2 to bind KPNA1 is diminished in the presence of VP24, and cells transiently expressing VP24 redistribute hnRNP C1/C2 from the nucleus to the cytoplasm. PMID: 21987768
15. This study reports the identification and classification of importin alpha 5 -interacting proteins in brain cells. PMID: 21307607
16. The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells. PMID: 21209321
17. Impalpha5 acts as a chaperone until Influenza a virus nucleoprotein (NP) is delivered in the nucleus for viral RNA encapsidation. PMID: 20974480
18. Study identified the sequences KKKRR, KKKRK, and KKRKK as the optimal sequences for binding to this site for mouse importin-alpha2, human importin-alpha1, and human importin-alpha5, respectively. PMID: 20406804
19. The papillomavirus E2 proteins preferentially interacted with alpha importins 3 and 5, and showed very weak or no interaction with the other three widely expressed alpha importins (alpha1, alpha 4, and alpha 7). PMID: 20193720
20. The VP24 IFN antagonist function of ebolavirus requires the ability of VP24 to interact with KPNalpha. PMID: 19889762
21. arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5 PMID: 12048190
22. one importin alpha molecule is able to use either its N- or C-terminal arm repeats for binding various NLS containing proteins PMID: 12740372
23. Importin alpha5 and alpha7 bind to Stat3 upon cytokine stimulation. PMID: 16298512
24. the karyopherin alpha NPI-1, a nuclear import adaptor, bound more strongly to Epstein-Barr virus nuclear antigen 1 Ser385-phosphorylated nuclear localization signal than to any other phosphorylated or nonphosphorylated forms PMID: 16439554
25. Here, VP24 is demonstrated to interact with endogenous karyopherin alpha1 and inhibits its interaction with STAT1. PMID: 17928350
26. importins alpha5 and beta1 associate with Nrf2, an interaction that was blocked by the nuclear import inhibitor SN50 PMID: 18238777
27. NPI-1 subfamily accumulates in the nucleus in response to oxidative stress, like importin alpha1/Rch1. PMID: 18707546
28. significant KPNA1-, NLRP1- and NLRP3-gene expression phenotypes associated with human genotypes of Crohn's disease, Huntington's disease and rheumatoid arthritis PMID: 19001869
29. PB2 interaction with alpha-importins is required for virus RNA replication. PMID: 19066626
30. Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. PMID: 19118899

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HGNC: 6394

OMIM: 600686

KEGG: hsa:3836

STRING: 9606.ENSP00000343701

UniGene: Hs.161008