Recombinant Human Inositol hexakisphosphate kinase 1 (IP6K1)

Code CSB-YP011770HU
MSDS
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Source Yeast
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Code CSB-EP011770HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011770HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP011770HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
IP6K1
Uniprot No.
Alternative Names
ATP:1D myo inositol hexakisphosphate phosphotransferase; IHPK1; Inositol hexakisphosphate kinase 1; Inositol hexaphosphate kinase 1; InsP6; InsP6 kinase 1; Ip6k1; IP6K1_HUMAN; Itpk6; Pi uptake stimulator; PiUS
Species
Homo sapiens (Human)
Expression Region
1-441
Target Protein Sequence
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTTER EQPRRKHSRR SLHRSGSGSD HKEEKASLSL ETSESSQEAK SPKVELHSHS EVPFQMLDGN SGLSSEKISH NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRAESCL DRRSEMRLKH LDMVLPEVAS SCGPSTSPSN TSPEAGPSSQ PKVDVRMIDF AHSTFKGFRD DPTVHDGPDR GYVFGLENLI SIMEQMRDEN Q
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Gene References into Functions
  1. IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate. PMID: 28154132
  2. provides the first evidence for the involvement of IP6Ks in dynein function and proposes that inositol pyrophosphate-mediated pyrophosphorylation may act as a regulatory signal to enhance dynein-driven transport PMID: 27474409
  3. IP6K1 is also involved in early cytoskeleton remodeling events during cancer progression. PMID: 27140681
  4. IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death. PMID: 25349427
  5. we identified IP6Ks as novel nuclear and cytosolic InsP6- (and InsP5-) dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio PMID: 24865181
  6. FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. PMID: 23322705
  7. IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus PMID: 15221640
  8. Results report the characterization of an inhibitor, N(2)-(m-(trifluoromethy)lbenzyl) N(6)-(p-nitrobenzyl)purine (TNP), selective for inositol hexakisphosphate kinases. PMID: 19208622

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Inositol phosphokinase (IPK) family
Database Links

HGNC: 18360

OMIM: 606991

KEGG: hsa:9807

STRING: 9606.ENSP00000323780

UniGene: Hs.386168

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