IP6K1 Antibody

Code CSB-PA011770LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate
    All lanes: IP6K1 antibody at 3.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 51, 32 kDa
    Observed band size: 51 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IP6K1 Polyclonal antibody
Uniprot No.
Target Names
IP6K1
Alternative Names
ATP:1D myo inositol hexakisphosphate phosphotransferase antibody; IHPK1 antibody; Inositol hexakisphosphate kinase 1 antibody; Inositol hexaphosphate kinase 1 antibody; InsP6 antibody; InsP6 kinase 1 antibody; Ip6k1 antibody; IP6K1_HUMAN antibody; Itpk6 antibody; Pi uptake stimulator antibody; PiUS antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Inositol hexakisphosphate kinase 1 protein (1-441AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The IP6K1 Antibody (Product code: CSB-PA011770LA01HU) is Non-conjugated. For IP6K1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA011770LB01HU IP6K1 Antibody, HRP conjugated ELISA
FITC CSB-PA011770LC01HU IP6K1 Antibody, FITC conjugated
Biotin CSB-PA011770LD01HU IP6K1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Gene References into Functions
  1. IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate. PMID: 28154132
  2. provides the first evidence for the involvement of IP6Ks in dynein function and proposes that inositol pyrophosphate-mediated pyrophosphorylation may act as a regulatory signal to enhance dynein-driven transport PMID: 27474409
  3. IP6K1 is also involved in early cytoskeleton remodeling events during cancer progression. PMID: 27140681
  4. IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death. PMID: 25349427
  5. we identified IP6Ks as novel nuclear and cytosolic InsP6- (and InsP5-) dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio PMID: 24865181
  6. FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. PMID: 23322705
  7. IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus PMID: 15221640
  8. Results report the characterization of an inhibitor, N(2)-(m-(trifluoromethy)lbenzyl) N(6)-(p-nitrobenzyl)purine (TNP), selective for inositol hexakisphosphate kinases. PMID: 19208622

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Inositol phosphokinase (IPK) family
Database Links

HGNC: 18360

OMIM: 606991

KEGG: hsa:9807

STRING: 9606.ENSP00000323780

UniGene: Hs.386168

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