Recombinant Human Inositol oxygenase (MIOX)

Code CSB-YP866220HU
MSDS
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Source Yeast
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Code CSB-EP866220HU
MSDS
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Source E.coli
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Code CSB-EP866220HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP866220HU
MSDS
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Source Baculovirus
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Code CSB-MP866220HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
MIOX
Uniprot No.
Alternative Names
0610009I10Rik; AI314022; Aldehyde reductase-like 6; ALDRL6; C85427; Inositol oxygenase; Kidney-specific protein 32; KSP32; MGC90217; MI oxygenase; miox; MIOX_HUMAN; Myo-inositol oxygenase; Renal-specific oxidoreductase; RSOR
Species
Homo sapiens (Human)
Expression Region
1-285
Target Protein Sequence
MKVTVGPDPS LVYRPDVDPE VAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGRD YQQLCSQQDL AMLPWVREFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Gene References into Functions
  1. Our results suggest that serum MIOX levels do not change in polycystic ovary syndrome. It was, therefore, concluded that myoinositol deficiency observed in PCOS was not related to the level of MIOX enzyme which cleaves myoinositol. PMID: 29187000
  2. these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy. PMID: 28208054
  3. Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues. PMID: 26578517
  4. results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population PMID: 19896870
  5. Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein. PMID: 15504367
  6. expression of MIOX is up-regulated by a positive feedback mechanism where xylitol, one of the products of MI catabolism via the glucuronate-xylulose pathway, induces an overexpression of MIOX PMID: 15778219
  7. myo-inositol oxygenase (MIOX) PMID: 11716759

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Subcellular Location
Cytoplasm.
Protein Families
Myo-inositol oxygenase family
Tissue Specificity
Kidney specific.
Database Links

HGNC: 14522

OMIM: 606774

KEGG: hsa:55586

STRING: 9606.ENSP00000216075

UniGene: Hs.129227

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