Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

IFNA4

Uniprot No.

P05014

Research Area

Cancer

Alternative Names

IFNA4Interferon alpha-4; IFN-alpha-4; Interferon alpha-4B; Interferon alpha-76; Interferon alpha-M1

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

24-189aa

Target Protein Sequence

CDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

35.4kDa

Protein Length

Partial

Tag Info

N-terminal 6xHis-SUMO-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The region for expressing recombinant Human IFNA4 contains amino acids 24-189. The expected molecular weight for the IFNA4 protein is calculated to be 35.4 kDa. This IFNA4 protein is produced using e.coli expression system. The IFNA4 gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant IFNA4 protein during the following stages.

Human interferon alpha-4 (IFNA4) is a member of the interferon-alpha family, a group of cytokines that play a crucial role in the antiviral immune response. IFNA4 is produced by various immune cells, particularly leukocytes, in response to viral infections. Its main function is to inhibit viral replication and spread by inducing the expression of antiviral proteins within infected cells. Additionally, IFNA4 contributes to the activation of immune cells, enhancing the overall antiviral defense. Research on IFNA4 spans virology, immunology, and clinical medicine, exploring its potential therapeutic applications in treating viral infections, certain cancers, and autoimmune diseases.

Target Background

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene References into Functions

Heterozygous IFNA4 variants is a cause of impaired function and CD-susceptibility genes in Chinese individuals from multiple center based study. PMID: 26000985
suppression of IFN signaling and IFN production by SOC3 occurs during HSV-1 infection PMID: 15163721

Subcellular Location

Secreted.

Protein Families

Alpha/beta interferon family

Database Links

HGNC: 5425

OMIM: 147564

KEGG: hsa:3441

STRING: 9606.ENSP00000412897

UniGene: Hs.1510

Code	CSB-EP011040HU
Abbreviation	Recombinant Human IFNA4 protein, partial
MSDS	MSDS Datasheet
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Interferon alpha-4 (IFNA4), partial

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