Recombinant Human Interleukin-28A(IL28A),Mammalian cell

Code CSB-MP816921HU
Product Type Recombinant Protein
Size Pls inquiry other sizes
Uniprot No. Q8IZJ0
Abbreviation IL28A
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity >85% (SDS-PAGE)
Sequence VPVAR LHGALPDARG CHIAQFKSLS PQELQAFKRA KDALEESLLL KDCRCHSRLF PRTWDLRQLQ VRERPMALEA ELALTLKVLE ATADTDPALV DVLDQPLHTL HHILSQFRAC IQPQPTAGPR TRGRLHHWLY RLQEAPKKES PGCLEASVTF NLFRLLTRDL NCVASGDLCV
Source Mammalian cell
Gene Names IFNL2
Protein Names Recommended name: Interleukin-28A Short name= IL-28A Alternative name(s): Cytokine Zcyto20 Interferon lambda-2 Short name= IFN-lambda-2
Expression Region 26-200
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Product Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
If we fail in developing the specified tag, we will send other tag type directly without negotiation.
Protein Description Full Length of Mature Protein
Target Details This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
HGNC 18364
MGI 3647279
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Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets
Subcellular location Secreted
Pathway Jak-STAT signaling pathway

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