IFNL2 Antibody

Code CSB-PA005422
Size US$167
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  • Western Blot analysis of MCF7 cells using IL-28 Polyclonal Antibody
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Product Details

Uniprot No. Q8IZJ0
Target Names IFNL2
Alternative Names Cytokine ZCYTO20 antibody; IFN-lambda-2 antibody; IFNL2 antibody; IL-28A antibody; IL28A antibody; IL28A_HUMAN antibody; Interferon lambda 2 antibody; Interferon lambda-2 antibody; interleukin 28A (interferon, lambda 2) antibody; Interleukin 28A antibody; Interleukin-28A antibody; ZCYTO20 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the C-terminal region of Human IL-28.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets
Gene References into Functions
  1. NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1, IFN-beta, IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 phosphorylation. PMID: 26353965
  2. Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29), IFN-lambda2 (IL28A), IFN-lambda3 (IL-28B) and IFN-lambda4. PMID: 26194286
  3. These results show that type III interferons (IFN-lambdas) play a critical protective role in human metapneumovirus infection. PMID: 25355870
  4. Results showed no association between genotypes and alleles of IL28A, IL28B or IL29 polymorphisms and Hepatitis C virus infection. PMID: 24269996
  5. this study provides evidence for potential IL-28A participation in Behcet's diseaseand its value as a therapeutic agent. PMID: 24973639
  6. Interferon regulatory factor (IRF)-3 and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B genes, whereas NF-kappaB is an additional requirement for the induction of the IL-29 gene. PMID: 24385435
  7. The results show that IL-28A/IL-28AR1 dyad-induced wound healing migration requires NF-kappaB-mediated MMP-9 expression by MAPK activation. PMID: 22560878
  8. IL-28 genotype was not associated with response to interferon treatment (OR for GT/GG vs. TT, 0.881 (95%CI 0.388 - 2.002); P = 0.762; OR for CT/CC vs. TT, 0.902 (95%CI 0.458 - 1.778); P = 0.766). PMID: 23652058
  9. IFN-lambdas can also directly affect T cells through inhibition of the T helper 2 cell (Th2) responses. IFN-lambdas have varying immunomodulatory functions under different physiological conditions PMID: 23207147
  10. p38 MAPK pathway mediates IL-28A-induced cell migration through MMP-9 expression by activating NF-kappaB and AP-1 binding motifs. PMID: 22825757
  11. Elevated expression of inflammatory cytokines (IL-5, IL-20, and IL-28A) is associated with bladder cancer development. PMID: 22962576
  12. Plasmacytoid dendritic cells are major producers of IFN-lambda2 (a type III interferon) in response to viral stimulation. PMID: 22891284
  13. This study aimed to 1) examine DNA sequences in IL28B surrounding each of the reported associated single nucleotide polymorphisms and the corresponding regions in IL28A. PMID: 22253847
  14. IL-29/IL-28A suppress herpes simplex virus type 1 (HSV-1) infection of human NT2-N neurons. PMID: 21499846
  15. In general IL-29 serum levels exceeded IL-28A/B at least twofold, with IL-29 and IL-28A/B levels being significantly higher in carriers of the rs12979860 C allele than in TT homozygous individuals in hepatitis C PMID: 21145813
  16. In contrast to IL-29, IL-28A is a potent gene repressor in patients with hepatitis C PMID: 21170333
  17. Observational study of gene-disease association. (HuGE Navigator) PMID: 20576307
  18. Chronic hepatitis C patients with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus. PMID: 20235331
  19. study supports that IFN-lambdas do not influence every type of cell and that membrane-associated variant IFN-lambda R1 expression is not sufficient to ensure cellular sensitivity toward these cytokines. PMID: 19798076
  20. identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family PMID: 12469119
  21. closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 PMID: 12483210
  22. IL-28A and IL-29 induced mRNA expression of the antiviral proteins 2',5'-OAS and MxA was abolished by overexpression of SOCS-1 PMID: 15850793
  23. we found IL-28A and IL-29 act similarly to IFNs, but are less effective generally and have activity in a more limited range of cell lines PMID: 15899585
  24. IECs express functional receptors for IFN-lambdas, which mediate antiviral and antiproliferative signals in IECs, suggesting a potential for therapeutic use in certain viral infections and as (antiproliferative) anticancer therapy PMID: 16051921
  25. IL-28A antiviral activity is associated with the activation of the JAK-STAT signaling pathway and expression of ISGs. PMID: 16146571
  26. IFN-lambdas are thus able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions PMID: 16478884
  27. IFNs lambda exhibit several common features with type I IFNs: antiviral activity, antiproliferative activity and in vivo antitumour activity [review] PMID: 17367910
  28. These data provide direct and compelling evidence that IFN-lambda, through both extracellular and intracellular antiviral mechanisms, inhibits HIV-1 replication in macrophages. PMID: 19193806
  29. recent findings about the biology of IFN-lambdas and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms.[review] PMID: 19304895

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Subcellular Location Secreted
Protein Families Lambda interferon family
Database Links

HGNC: 18364

OMIM: 607401

KEGG: hsa:282616

STRING: 9606.ENSP00000333639

UniGene: Hs.567792

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