Recombinant Human Interleukin-6 receptor subunit beta(IL6ST),partial

Code CSB-YP011667HU
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Source Yeast
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Code CSB-EP011667HU
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Source E.coli
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Code CSB-EP011667HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011667HU
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Source Baculovirus
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Code CSB-MP011667HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names IL6ST
Uniprot No. P40189
Alternative Names CD130; CD130 antigen; CDw130; gp130; GP130 RAPS; IL 6R beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6 ST; IL6RB_HUMAN; IL6ST; Interleukin 6 receptor subunit beta; Interleukin receptor beta chain ; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; Membrane glycoprotein gp130; Oncostatin M receptor ; Oncostatin M receptor alpha subunit; Oncostatin-M receptor subunit alpha
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases
Gene References into Functions
  1. Low soluble glycoprotein 130 (sgp130) level may serve as an additional indicator of coronary atherosclerosis severity. PMID: 29580104
  2. we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex. PMID: 29237553
  3. SNP rs10940495 in the gp130 locus was associated with functional outcome at 6 months following spontaneous intracerebral hemorrhage. PMID: 28964648
  4. Low levels of serum sgp130 were positively associated with sex hormones in male patients with coronary artery disease, suggesting an important role of sgp130 in the presence of low and imbalanced sex hormones levels. PMID: 29028483
  5. Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130. PMID: 29038846
  6. gp130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer. PMID: 27917904
  7. GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. PMID: 28356514
  8. Data show that tumor suppressor adenomatous polyposis coli (APC) loss results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating YAP (YY1-associated) protein (YAP) which are simultaneously up-regulated in the majority of colorectal cancer (CRC). PMID: 28130546
  9. an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation. PMID: 27489351
  10. age 3 plasma levels of sGP130 were found related to childhood asthma PMID: 27434124
  11. This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease. PMID: 27053713
  12. we developed a CRISPR-Cas9-based tool for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation of a wider promoter region of the target loci IL6ST and BACH2 decreased their expression PMID: 26969735
  13. Intracellular p19 associated with the cytokine receptor subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3) signaling PMID: 26980441
  14. High serum GP130 levels were associated with Chronic Spontaneous Urticaria. PMID: 26699882
  15. Mutations leading to constitutive active gp130/JAK1/STAT3 pathway. PMID: 26188635
  16. In the present study, we analyze the role of a unique cysteine residue (Cys-628) within this C-terminus, which is contained neither in the membrane-bound gp130 nor in the two other sgp130 forms. PMID: 26809098
  17. pulmonary exposure to MWCNT can manifest as a reduced epithelial barrier and activator of vascular gp130-associated transsignaling that may promote susceptibility to cardiovascular derangements PMID: 26589480
  18. Diabetic rats show an increase in the contractions of distal colon partly via the IL-6-IL-6 receptor pathway. PMID: 26191141
  19. Data (including data from molecular dynamics simulation studies) suggest that conformation of GP130 (domains 2 and 3) changes and fluctuates only modestly (inter-domain angles vary only 125-140 degrees). PMID: 25243707
  20. GP130 signaling collaborated with MYC to induce MM and was responsible and sufficient for directing the plasma cell phenotype. PMID: 25384216
  21. GP130/STAT3 pathway is activated in NAFLD and can worsen insulin resistance while protecting against other lipotoxic mechanisms of disease pathogenesis. PMID: 25747354
  22. NDRG2/gp130/STAT3 pathway can mediate the antimetastatic effects of Dp44mT in hepatocellular carcinoma. PMID: 25261367
  23. Candidate gene IL6ST were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status. PMID: 24656773
  24. Recombinant sgp130-E10Fc binds to a complex of IL-6 and sIL-6R, but not to IL-6 alone, and specifically inhibits IL-6 trans-signaling. Thus, it might play an important role in the regulation of trans-signaling in vivo. PMID: 24973212
  25. Low incidence of IL6ST mutations in exon 6 are associated with lung cancer. PMID: 25242236
  26. However, activation of the gp130 cell surface receptor is both necessary and sufficient for downregulation of TGF-beta2 in Kaposi's sarcoma-associated herpesvirus-infected cells. PMID: 25275137
  27. This review showed that Humanin is a a possible linkage between Alzheimer's disease and type 2 diabetes. PMID: 24365186
  28. Aberrant signalling from intracellular compartments might explain the tumorigenic potential of naturally occurring somatic mutations of gp130. PMID: 24213527
  29. Data suggest women with inflammatory hepatic adenoma exhibit mutations in gp130/IL6ST (glycoprotein subunit 130, interleukin-6 receptor, HNF1A (hepatic nuclear factor 1 alpha), and CTNNB1 (beta-catenin). [REVIEW] PMID: 25076298
  30. serum level decreased in early onset severe pre-eclampsia PMID: 23782174
  31. ERK2 binds to the GP130 promoter, where it perhaps interacts with the transcriptional machinery. PMID: 23686311
  32. Sgp130 serum levels are significantly higher in subjects carrying the gp130 polymorphism G148C compared to wildtype carriers. PMID: 24629561
  33. Higher expression of p-p38, p-C-JUN, p-STAT3, and p-gp130 in the MBC-B group. PMID: 23813018
  34. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes PMID: 23536726
  35. Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130/JAK signaling pathway. PMID: 23818941
  36. CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells. PMID: 24191003
  37. Newly synthesized IL-6 drives association of the IL-6 receptor and gp130 with EGFR, leading to EGFR-dependent rephosphorylation of STAT3, which is not inhibited by the continued presence of SOCS3. PMID: 24082147
  38. Data suggest that soluble gp130 has a role in prostate cancer invasion in an interleukin-6 dependent and independent manner. PMID: 21944124
  39. Data suggest flavanoids (naringenin, flavone) suppress interleukin-6/IL6ST signaling and induce expression of SOCS3 (signal transducer and activator of transcription 3) in vascular endothelium; thus, dietary factors act as anti-inflammatory agents. PMID: 23782265
  40. gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. PMID: 23398366
  41. interleukin-6 receptor polymorphism may be a contributing factor in Castleman Disease, and further research is warranted. PMID: 23372742
  42. In a laboratory study, addition of gp130 to culture media improves blastocyst formation and implicates a physiological role in regulating preimplantation development in humans. PMID: 23375201
  43. Data indicate that active cruzipain completely abrogated the STAT3 phosphorylation and enzymatically cleaved gp130 ectodomain. PMID: 23253440
  44. An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. PMID: 23209286
  45. gp130 activation is regulated by D2-D3 interdomain connectivity. PMID: 23294003
  46. Gp130 mRNA was hardly detectable in endometrium of both fertile and infertile women with no difference between them. Infertile women secreted significantly less gp130 molecules in the uterine flushing compared with fertile women. PMID: 22520363
  47. Together these results suggest that the inhibitory effect of OSM on TGF-beta1-induced CTGF mRNA expression is mainly driven by STAT3, thereby providing a signaling mechanism whereby OSM may contribute to tubulointerstitial protection. PMID: 22814105
  48. the mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling PMID: 22523320
  49. gp130 regulates interleukin 6 signalling as an antagonist in cerebrospinal fluid immediately after subarachnoid haemorrhage PMID: 20660911
  50. The IL-6/gp130 signaling pathway is dierctly involved in amyloid-beta precursor protein (APP)-induced glial differentiation. PMID: 20309664

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Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted
Protein Families Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Database Links

HGNC: 6021

OMIM: 600694

KEGG: hsa:3572

STRING: 9606.ENSP00000338799

UniGene: Hs.532082

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