Recombinant Human M-phase inducer phosphatase 1 (CDC25A)

1. we uncovered the role of CDC25A in BRCA-mediated tumorigenesis, which can have implications in cancer treatment PMID: 29416040
2. Cdc25A negatively regulates the antiviral immune response by inhibiting TBK1 activity. PMID: 30021902
3. Study reveals that Cdc25A is elevated, activated and has an essential role in neuronal cell death evoked by apoptotic stimuli relevant to normal development and to AD. PMID: 28333146
4. EGFR activation results in c-Src-mediated Cdc25A phosphorylation at Y59, which interacts with nuclear pyruvate kinase M2 (PKM2). PMID: 27485204
5. our data also suggests the importance ofLIMD1 and CDC25A in conjunction with HPV for use as diagnostic and prognostic markers of HNSCC, whereas RBSP3 as a prognostic marker only. PMID: 29672635
6. Inhibition of YBX1 suppressed lung cancer growth partly via the CDC25a pathway and high expression of YBX1/CDC25a predicts poor prognosis in human lung adenocarcinoma. PMID: 27384875
7. MCPH1 interacts with and promotes the E3 ligase betaTrCP2 to degrade Cdc25A independent of DNA damage. Overexpression of betaTrCP2 or the knockdown of Cdc25A remedies the high mitotic index and rescues the premature differentiation of Mcph1-deficient neuroprogenitors in vivo MCPH1 itself is degraded by APC/CCdh1, but not APC/CCdc20, in late mitosis and G1 phase. PMID: 29150431
8. The cytoplasmic relocalization of CDC25A in skin cancers results in acquisition of an antiapoptotic function for CDC25A. PMID: 28951130
9. NPAS2 has a critical role in HCC cell survival and tumor growth, which is mainly mediated by transcriptional upregulation of CDC25A. PMID: 28333141
10. Results identify cyclinD-CDK4/6 complexes as novel regulators of CDC25A stability during G1 phase, generating a negative feedback loop allowing control of the G1/S transition. PMID: 28192398
11. These results identify a new positive regulatory loop between Cdc25A and its CDK-cyclin substrates which contributes to accelerate entry into mitosis through the regulation of Cdc25A activity in G2. PMID: 27580187
12. The expression level of Cdc25A was significantly increased (<0.05) after treatment with miR-675 mimics. PMID: 27644634
13. miR-497 modulates the growth of chondrosarcoma cells by targeting Cdc25A. PMID: 27053344
14. This study demonstrated that the cell cycle pathway and the cdc25a gene may be crucial in the pathogenesis and progression of hepatocellular carcinoma. PMID: 26647881
15. Increased CDC25A is associated with invasiveness in Non-small Cell Lung Cancer. PMID: 25990966
16. Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM. PMID: 26474275
17. Identify CDC25A as an early cell cycle transducer of FLT3-ITD oncogenic signaling, and as a promising target to inhibit proliferation and re-induce differentiation of FLT3-ITD acute myeloid leukemia cells. PMID: 26515730
18. STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation. PMID: 25936524
19. let-7c suppresses HCC progression, possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules. Let-7c may therefore be an effective therapeutic target for HCC. PMID: 25909324
20. Results suggest that miR-449a may act as a tumor suppressor by targeting CDC25A in endometrial cancer. PMID: 24993091
21. CDC25C seems important for the phenotype of AML cells at least for a subset of patients. Many of the identified CDC25 inhibitors show cross-reactivity among the three CDC25 isoforms. PMID: 25397735
22. Our results suggest that expression of CDC25B may be used as a potential prognostic marker in the pathogenesis of retinoblastoma. PMID: 25326518
23. These results suggest that Cdc25a promotes human cytomegalovirus replication and elevation of Cdc25a levels after human cytomegalovirus infection are due in part to human cytomegalovirus-mediated repression of miR-21. PMID: 25378484
24. miR-424(322)/503-dependent posttranscriptional downregulation of CDC25A cooperates with transcriptional repression of the CDC25A promoter and proteasome-mediated degradation to reduce the levels of CDC25A expression and to induce cell cycle arrest. PMID: 25266660
25. Findings suggest that inhibition of H19 long non-coding RNA (LncRNAH19) and miR-675 expression can promote migration and invasion of hepatocellular carcinoma (HCC) cells via AKT/GSK-3beta/Cdc25A signaling pathway. PMID: 24939300
26. accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A PMID: 24211536
27. CDC 25A dephosphorylates NFAT, resulting in translocation to nucleus and NFAT in co-operation with Smad2 promotes the tumor progression. PMID: 24269534
28. RSK promotes G2/M transition in mammalian cells through activating phosphorylation of Cdc25A and Cdc25B PMID: 23708659
29. Overexpression of CDC25A was associated with the decrease of overall survival rates and disease-free survival in breast cancer patients.CDC25a is a target of HER2 signaling in human breast cancer. PMID: 23730206
30. Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. PMID: 23675485
31. Data indicate that protein phosphatase inhibitor RE142 binds to one of the residues Cys384-Tyr386 of CDC25A, within a pocket adjacent to the catalytic site. PMID: 23467652
32. Our work provides novel insight into the underlying mechanisms by which FOXM1 controls the cell cycle through its association with CDC25A. PMID: 23240008
33. destabilization of Cdc25A through inhibition of Hsp90 was boosted by the phosphorylation of Ser177 which tags Cdc25A to proteasomal degradation and this added up to the cell-cycle inhibitory effect PMID: 22843495
34. A new role for Rock2 in modulation of Cdc25A ubiquitination has been revealed, indicating a novel mechanism of Cdc25A regulation and a potential function for Rock2 in the development of hepatocellular carcinoma. PMID: 22705122
35. Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2-p53-Cdc25A-p21-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis. PMID: 22160829
36. Cdc25A has an important physiological role in NF-kappaB activity regulation and it may be an important survival mechanism of cancer cells. PMID: 22417828
37. CDC25A deregulation may be involved in hematopoietic cells expansion in JAK2(V617F) patients, making this protein an attracting potential therapeutic target. PMID: 22065597
38. Cdc25A enhances Foxo1 stability by dephosphorylating Cdk2, and Foxo1 was shown to directly regulate transcription of the metastatic factor MMP1. PMID: 21670150
39. High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/beta-catenin target gene, CDC25A. PMID: 21575861
40. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis. PMID: 20956543
41. This study demonistratef that the expression levels of CDC25s in human gliomas, and found that CDC25A is overexpressed, and significantly correlate with Ki-67 expression. PMID: 20217459
42. Results reveal an unexpected role of Cdc25A down-regulation and the inhibitory phosphorylation of cdk2 T14 and Y15 in cell cycle quiescence during muscle differentiation and implicate miRNAs-322 and -503 in the process. PMID: 20462953
43. 263C/T and -51C/G polymorphisms of CDC25A gene could be candidate markers for earlier diagnosis and targets for breast cancer therapy. PMID: 20614206
44. results suggest TRB3 is a regulator for adjusting the expression level of Cdc25A both in a normal and a genotoxic conditions PMID: 20606298
45. 14-3-3 protein gamma mediates the interaction between Checkpoint kinase 1 and Cdc25A. PMID: 20639859
46. Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. PMID: 20348946
47. NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation. PMID: 20090422
48. As a major regulator of Cdc25A, Dub3 is an example of a transforming ubiquitin hydrolase that subverts a key component of the cell cycle machinery, promoting oncogenic transformation. PMID: 20228808
49. The reduction in Cdc25A mRNA and protein was dependent on the cyclin-dependent kinase inhibitor p21 and miR-21, which were upregulated in HCT116 colon cancer cells during hypoxia. PMID: 19738433
50. Results demonstrate by RNA interference that Sp1 regulating CDC25A and FAS expression and proliferation in cancer cells. PMID: 19621387

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HGNC: 1725

OMIM: 116947

KEGG: hsa:993

STRING: 9606.ENSP00000303706

UniGene: Hs.437705