Recombinant Human Neurogenic locus notch homolog protein 4 (NOTCH4), partial

1. Results provide evidence that Notch4 plays an important role in vasculogenic mimicry formation and tumor invasion in hepatocellular carcinoma. PMID: 29058285
2. The results of the present study show that RNA interference targeting against Notch-4 expression suppresses prostate cancer progression. PMID: 28374086
3. Very rare missense variant in the regulatory NODP domain of NOTCH4 located at the 6p21 locus was identified in a single family.This family suggests a novel mechanism of systemic sclerosis pathogenesis in which a rare and penetrant coding variation can substantially elevate disease risk in contrast to the more modest non-coding variation typically found at this locus. PMID: 27829420
4. High NOTCH4 expression is associated with preeclampsia. PMID: 27069008
5. Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma. PMID: 26472724
6. findings indicate that Notch4+ melanoma cancer stem-like cells trigger epithelial-mesenchymal transition and promote the metastasis of melanoma cells PMID: 27234159
7. the aberrant activation of Notch4 promotes oral squamous cell carcinoma metastasis. PMID: 27197026
8. data are consistent with those obtained in previous studies that suggested that rs204993 is associated with schizophrenia and that the AA genotype of rs204993 demonstrates a higher risk PMID: 26605328
9. High Notch4 expression is associated with Prostatic Intraepithelial Neoplasia. PMID: 26341090
10. Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity. PMID: 26387946
11. NOTCH4 polymorphism can influence clinical symptoms in Slovenian patients with schizophrenia. PMID: 25529856
12. Our findings provide a novel mechanism for Notch4-ICD regulation, suggesting a negative regulatory role for the PI3K-AKT pathway in Notch4 nuclear signaling. PMID: 25740432
13. This study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for schizophrenia. PMID: 25142293
14. BITC-mediated inhibition of bCSC was augmented by knockdown of Notch4 and Nicastrin, but not by RNA interference of Notch1 or Notch2. PMID: 25663545
15. Study shows that Notch4 activation can promote gastric cancer growth by inducing Wnt1/b-catenin signaling. PMID: 25511451
16. A genome-wide significant association with cryoglobulin-related vasculitis was identified with SNPs near NOTCH4. PMID: 25030430
17. This paper demonstrated that Nicastrin and Notch4 are key molecules involved in resistance to endocrine therapy. The data suggest that targeting Notch4 and Nicastrin is a potential approach to reverse endocrine resistance in breast cancer patients. PMID: 24919951
18. The associations of rs2616984 in CSMD1 gene, putative associations of rs3131296 in NOTCH4 gene, and associations of rs2229741 of NRIP1 gene with Alzheimer's disease have been found in a Russian population. PMID: 25845235
19. The expression of NOTCH4 in the dorsolateral prefrontal cortex and amygdala is decreased in suicide victims compared to control brain. PMID: 24151014
20. High Notch4 expression is associated with glioblastoma multiforme. PMID: 24305720
21. This NOTCH4 missense mutation decreased the risk for developing multiple sclerosis in Japanese, but did not affect clinical features of those who had already developed the disease PMID: 23549433
22. A possible contribution of Notch4 signalling to the development of brain arteriovenous malformations in human. PMID: 24373503
23. NOTCH4 overexpression is associated with triple-negative breast cancer. PMID: 24403446
24. RNAi directed against Notch-4 markedly decreased Notch-4 gene expression. PMID: 23450325
25. The results of this study provided stringent support for previous genetic findings reporting the association of an intronic SNP (rs3131296, chr6: 32 172 993 bp on hg19) in NOTCH4 in a European cohort. PMID: 22641179
26. The length of (CA)n in EGFR and (CTG)n in NOTCH4 was not associated with breast cancer (OR=0.99; 95% CI 0.59-1.37; p=0.619 and OR=1.08; 95% CI 0.71-1.65; p=0.725, respectively). PMID: 23015403
27. Our study shows that genetic variations within the NOTCH4 gene significantly modify the clinical characteristics of migraine and may have a role in disease pathogenesis. PMID: 23566281
28. We provide the first genetic evidence suggesting the involvement of NOTCH4 polymorphisms in rheumatoid inflammatory process. PMID: 23318300
29. Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in proximal tubular epithelial cells exposed to shear stress. PMID: 23576639
30. These data suggest that N4IC promoted proliferation through modulating the ERK pathway and the cell cycle during the early stage of 3T3-L1 adipogenesis and facilitated differentiation through up-regulating adipogenic genes such as C/EBPalpha, PPARgamma, aP2, LPL and HSL during the middle and late stages of 3T3-L1 adipogenesis. PMID: 23237809
31. strong association between expression and bipolar disorder PMID: 23212060
32. Genome-wide association study of age-related macular degeneration identifies TNXB, FKBPL and NOTCH4 as candidate susceptibility genes. PMID: 22694956
33. Functional interaction of Notch4(ICD) and Elongin C provides novel insight into regulation of Notch signaling in epithelial cell biology and disease. PMID: 22001063
34. the NOTCH4 polymorphisms, the minor allele of rs422951 and the 12-repeat variation for rs72555375, can be considered to be markers for sporadic inclusion body myositis susceptibility PMID: 22732452
35. The NOTCH4 polymorphisms most strongly associated with schizophrenia exert their effects on susceptibility by altering the efficiency and/or alternative splicing of Notch4 transcripts. PMID: 22488909
36. arachidonic acid significantly decreased methylation of the promoters of both KDR and Notch4 genes in Human umbilical vein endothelial cells. PMID: 21864059
37. Only rs17604492 single nucleotide polymorphism of NOTCH4 gene was found to be weakly associated with susceptibility to Kawasaki Disease (KD) in a Korean population. Results indicate NOTCH4 doesn't contribute to susceptibility to KD. PMID: 21203870
38. This research examined the methylation status of a region surrounding the NOTCH4 -25 C/T site in leukocyte genomic DNA and human brain regions. PMID: 21085055
39. Studies indicate that different receptors and ligands expression in breast cancer and various ways in which the pathway can be inhibited. PMID: 21045140
40. Notch-4 may play an important role in salivary adenoid cystic carcinoma. PMID: 20596622
41. Notch 4 receptors and their ligands play differential roles in the cytodifferentiation of squamous odontogenic tumors of the mandible. PMID: 20554499
42. Notch4 signaling activity was 8-fold higher in breast cancer stem cell-enriched cell populations compared with differentiated cells, whereas Notch1 signaling activity was 4-fold lower in the stem cell-enriched cell populations. PMID: 20068161
43. The Notch gene family regulates embryonic cell migration, vascular morphogenesis and remodeling. The Notch 4 locus has been implicated in schizophrenia, but this study rules out a significant role for the Notch4 gene in schizophrenia in the Han Chinese. PMID: 11803454
44. Genetic analysis of (CTG)n polymorphism in bipolar pedigrees PMID: 11901359
45. Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. PMID: 11909975
46. significant association of alopecia areata in the overall data set with the Notch4(T+1297C) polymorphism (P<0.001) but not with Notch4(A+3063G) PMID: 12589427
47. The investigated NOTCH4 variants do not have a major influence on susceptibility to schizophrenia or related neurobiological traits. PMID: 12605097
48. Findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development. PMID: 12627456
49. NOTCH4 T-25C polymorphism has an important effect on the age of onset in schizophrenia. PMID: 12782960
50. Notch4 signaling in vascular endothelial cells. PMID: 12814948

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HGNC: 7884

OMIM: 164951

KEGG: hsa:4855

STRING: 9606.ENSP00000364163

UniGene: Hs.436100