Recombinant Human Neurogenic locus notch homolog protein 4(NOTCH4) ,partial

Code CSB-YP860341HU
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Source Yeast
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Code CSB-EP860341HU
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Source E.coli
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Code CSB-EP860341HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP860341HU
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Source Baculovirus
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Code CSB-MP860341HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names NOTCH4
Uniprot No. Q99466
Alternative Names FLJ16302; hNotch 4; hNotch4; INT3; Neurogenic locus notch homolog protein 4; NOTC4_HUMAN; Notch 4; Notch 4 intracellular domain; Notch homolog 4; Notch4; NOTCH4 protein
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
Gene References into Functions
  1. Results provide evidence that Notch4 plays an important role in vasculogenic mimicry formation and tumor invasion in hepatocellular carcinoma. PMID: 29058285
  2. The results of the present study show that RNA interference targeting against Notch-4 expression suppresses prostate cancer progression. PMID: 28374086
  3. Very rare missense variant in the regulatory NODP domain of NOTCH4 located at the 6p21 locus was identified in a single family.This family suggests a novel mechanism of systemic sclerosis pathogenesis in which a rare and penetrant coding variation can substantially elevate disease risk in contrast to the more modest non-coding variation typically found at this locus. PMID: 27829420
  4. High NOTCH4 expression is associated with preeclampsia. PMID: 27069008
  5. Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma. PMID: 26472724
  6. findings indicate that Notch4+ melanoma cancer stem-like cells trigger epithelial-mesenchymal transition and promote the metastasis of melanoma cells PMID: 27234159
  7. the aberrant activation of Notch4 promotes oral squamous cell carcinoma metastasis. PMID: 27197026
  8. data are consistent with those obtained in previous studies that suggested that rs204993 is associated with schizophrenia and that the AA genotype of rs204993 demonstrates a higher risk PMID: 26605328
  9. High Notch4 expression is associated with Prostatic Intraepithelial Neoplasia. PMID: 26341090
  10. Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity. PMID: 26387946
  11. NOTCH4 polymorphism can influence clinical symptoms in Slovenian patients with schizophrenia. PMID: 25529856
  12. Our findings provide a novel mechanism for Notch4-ICD regulation, suggesting a negative regulatory role for the PI3K-AKT pathway in Notch4 nuclear signaling. PMID: 25740432
  13. This study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for schizophrenia. PMID: 25142293
  14. BITC-mediated inhibition of bCSC was augmented by knockdown of Notch4 and Nicastrin, but not by RNA interference of Notch1 or Notch2. PMID: 25663545
  15. Study shows that Notch4 activation can promote gastric cancer growth by inducing Wnt1/b-catenin signaling. PMID: 25511451
  16. A genome-wide significant association with cryoglobulin-related vasculitis was identified with SNPs near NOTCH4. PMID: 25030430
  17. This paper demonstrated that Nicastrin and Notch4 are key molecules involved in resistance to endocrine therapy. The data suggest that targeting Notch4 and Nicastrin is a potential approach to reverse endocrine resistance in breast cancer patients. PMID: 24919951
  18. The associations of rs2616984 in CSMD1 gene, putative associations of rs3131296 in NOTCH4 gene, and associations of rs2229741 of NRIP1 gene with Alzheimer's disease have been found in a Russian population. PMID: 25845235
  19. The expression of NOTCH4 in the dorsolateral prefrontal cortex and amygdala is decreased in suicide victims compared to control brain. PMID: 24151014
  20. High Notch4 expression is associated with glioblastoma multiforme. PMID: 24305720
  21. This NOTCH4 missense mutation decreased the risk for developing multiple sclerosis in Japanese, but did not affect clinical features of those who had already developed the disease PMID: 23549433
  22. A possible contribution of Notch4 signalling to the development of brain arteriovenous malformations in human. PMID: 24373503
  23. NOTCH4 overexpression is associated with triple-negative breast cancer. PMID: 24403446
  24. RNAi directed against Notch-4 markedly decreased Notch-4 gene expression. PMID: 23450325
  25. The results of this study provided stringent support for previous genetic findings reporting the association of an intronic SNP (rs3131296, chr6: 32 172 993 bp on hg19) in NOTCH4 in a European cohort. PMID: 22641179
  26. The length of (CA)n in EGFR and (CTG)n in NOTCH4 was not associated with breast cancer (OR=0.99; 95% CI 0.59-1.37; p=0.619 and OR=1.08; 95% CI 0.71-1.65; p=0.725, respectively). PMID: 23015403
  27. Our study shows that genetic variations within the NOTCH4 gene significantly modify the clinical characteristics of migraine and may have a role in disease pathogenesis. PMID: 23566281
  28. We provide the first genetic evidence suggesting the involvement of NOTCH4 polymorphisms in rheumatoid inflammatory process. PMID: 23318300
  29. Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in proximal tubular epithelial cells exposed to shear stress. PMID: 23576639
  30. These data suggest that N4IC promoted proliferation through modulating the ERK pathway and the cell cycle during the early stage of 3T3-L1 adipogenesis and facilitated differentiation through up-regulating adipogenic genes such as C/EBPalpha, PPARgamma, aP2, LPL and HSL during the middle and late stages of 3T3-L1 adipogenesis. PMID: 23237809
  31. strong association between expression and bipolar disorder PMID: 23212060
  32. Genome-wide association study of age-related macular degeneration identifies TNXB, FKBPL and NOTCH4 as candidate susceptibility genes. PMID: 22694956
  33. Functional interaction of Notch4(ICD) and Elongin C provides novel insight into regulation of Notch signaling in epithelial cell biology and disease. PMID: 22001063
  34. the NOTCH4 polymorphisms, the minor allele of rs422951 and the 12-repeat variation for rs72555375, can be considered to be markers for sporadic inclusion body myositis susceptibility PMID: 22732452
  35. The NOTCH4 polymorphisms most strongly associated with schizophrenia exert their effects on susceptibility by altering the efficiency and/or alternative splicing of Notch4 transcripts. PMID: 22488909
  36. arachidonic acid significantly decreased methylation of the promoters of both KDR and Notch4 genes in Human umbilical vein endothelial cells. PMID: 21864059
  37. Only rs17604492 single nucleotide polymorphism of NOTCH4 gene was found to be weakly associated with susceptibility to Kawasaki Disease (KD) in a Korean population. Results indicate NOTCH4 doesn't contribute to susceptibility to KD. PMID: 21203870
  38. This research examined the methylation status of a region surrounding the NOTCH4 -25 C/T site in leukocyte genomic DNA and human brain regions. PMID: 21085055
  39. Studies indicate that different receptors and ligands expression in breast cancer and various ways in which the pathway can be inhibited. PMID: 21045140
  40. Notch-4 may play an important role in salivary adenoid cystic carcinoma. PMID: 20596622
  41. Notch 4 receptors and their ligands play differential roles in the cytodifferentiation of squamous odontogenic tumors of the mandible. PMID: 20554499
  42. Notch4 signaling activity was 8-fold higher in breast cancer stem cell-enriched cell populations compared with differentiated cells, whereas Notch1 signaling activity was 4-fold lower in the stem cell-enriched cell populations. PMID: 20068161
  43. The Notch gene family regulates embryonic cell migration, vascular morphogenesis and remodeling. The Notch 4 locus has been implicated in schizophrenia, but this study rules out a significant role for the Notch4 gene in schizophrenia in the Han Chinese. PMID: 11803454
  44. Genetic analysis of (CTG)n polymorphism in bipolar pedigrees PMID: 11901359
  45. Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. PMID: 11909975
  46. significant association of alopecia areata in the overall data set with the Notch4(T+1297C) polymorphism (P<0.001) but not with Notch4(A+3063G) PMID: 12589427
  47. The investigated NOTCH4 variants do not have a major influence on susceptibility to schizophrenia or related neurobiological traits. PMID: 12605097
  48. Findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development. PMID: 12627456
  49. NOTCH4 T-25C polymorphism has an important effect on the age of onset in schizophrenia. PMID: 12782960
  50. Notch4 signaling in vascular endothelial cells. PMID: 12814948

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Subcellular Location Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
Protein Families NOTCH family
Tissue Specificity Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukoc
Database Links

HGNC: 7884

OMIM: 164951

KEGG: hsa:4855

STRING: 9606.ENSP00000364163

UniGene: Hs.436100

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