Recombinant Human P2X purinoceptor 4 (P2RX4), partial

1. Three single nucleotide polymorphisms (SNPs) within P2X4R and two SNPs within CAMKK2 influenced concentrations of TNFalpha in peripheral blood mononuclear cells, but these SNP did not associate with risk for HIV-associated sensory neuropathy in South Africans. PMID: 29428485
2. the data reveals a role for P2X4 in determining the duration of ATP-evoked Ca(2+) responses and CXCL5 secretion in human primary macrophage. PMID: 29255078
3. the data provides evidence that P2X4 is functionally expressed in THP-1 differentiated macrophages as reflected from their contribution towards ATP-evoked Ca2+ response, but their functional evidence in THP-1 monocyte is lacking. PMID: 29077063
4. Our study nominates rare genetic variants in P2RX4 and P2RX7 as major genetic contributors to disease, further supporting a role for these purinergic receptors in MS and the disruption of transmembrane cation channels leading to impairment of phagocytosis as the pathological mechanisms of disease PMID: 28326637
5. Overexpressing P2X4Rs on microglia are a central player in evoking neuropathic pain. (review) PMID: 28458288
6. the intersubunit physical couplings among the DF and two lower body domains fostered by the LF domain at the open state act as an integrated structural element that is stringently required for the channel gating of P2X4 receptors. PMID: 28302727
7. These findings provide new insights in understanding the contribution of the salt bridge between Asp-85 and Arg-309 and its structurally coupled beta2,3-sheet to the function of P2X4 receptors. PMID: 26865631
8. The results suggest a role of PrP(C) in proteostasis, dysfunctions of which may be involved in the pathogenesis of neurodegenerative diseases such as TSE and Alzheimer's Disease. PMID: 26946358
9. Fndings support role for P2X7 and P2X4 coupled to induction of inflammatory molecules in modulating high glucose and palmitate-induced endothelial cell activation and dysfunction. PMID: 25938443
10. This study demonstrates a major physiological finding that the shear-induced effects on endothelial KLF2 axis are in part dependent on ATP release and P2X4, a previously unidentified mechanism. PMID: 25563726
11. Using pHluorin, P2X4 was found to be expressed on the plasma membrane and within subcellular compartments in hippocampus. PMID: 24935743
12. It appears to mediate the cells' response to extracellular ATP. Although Ca2thorn influx via P2X1 receptor is necessary for alpha-synuclein accumulation. PMID: 25480524
13. P2X4 and calmodulin form a complex at endolysosomal membrane where P2X4 activation recruits calmodulin to promote fusion and vacuolation in a Ca(2+)-dependent fashion. PMID: 26101220
14. the lysosome-localized P2X4 may play specific roles in membrane trafficking of acidic organelles in mammalian cells. PMID: 24817123
15. P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation during P. gingivalis infection. PMID: 23936165
16. Results suggest that ATP-P2X4 signaling mediates high glucose-induced activation of the NLRP3 inflammasome. PMID: 23434541
17. These findings highlight Rab5 GTPase as a key regulator of P2X4 receptor cell surface expression and internalisation PMID: 23086000
18. This is the first study demonstrating an association of non-synonymous polymorphisms in the P2RX ( 4 ) and the risk of osteoporosis, suggesting a role of the P2X ( 4 ) R in the regulation of bone mass PMID: 23138503
19. results demonstrate that a haplotype including two rare variants in P2RX7 and P2RX4 confers a functional interaction between these two variant receptors that impairs the normal scavenger function of macrophages and microglia PMID: 23303206
20. IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation. PMID: 22996386
21. The present article highlights the recent advances in our understanding of microglia-neuron interactions in neuropathic pain by focusing on the signaling and regulation of the P2X4R--{REVIEW} PMID: 22528681
22. We demonstrate here that stimulation with ADP or ATP induces significant reversible inhibition of C. trachomatis development in cervical epithelial cells through stimulation of the purinergic receptor P2X4. PMID: 22988022
23. found that pharmacological inhibition of P2X4 receptors with TNP-ATP inhibited transcriptional up-regulation of TNF-alpha and IFN-gamma in gammadelta T cells stimulated with anti-CD3/CD28-coated beads PMID: 22753954
24. Neuropathic pain may be driven by P2X4R+ microglia. PMID: 22837036
25. Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals PMID: 22219189
26. Transcripts of five different isoforms of P2X4 receptors are expressed in human liver cells indicating that they represent an important component of the purinergic signaling complex in HCV induced liver pathogenesis. PMID: 21899776
27. The Tyr315>Cys mutation (rs28360472) reduced the peak amplitude of the ATP-induced inward current. In Victorian Family Heart Study participants, 1 minor allele increased pulse pressure by 2.84 mm Hg. PMID: 22068874
28. Owing to their favorable diameters and equivalent spacing, the lateral portals split the task of ion supply threefold and minimize an ion's diffusive path before it succumbs to transmembrane electrochemical gradients PMID: 21808018
29. we have identified an extracellular signaling pathway where Tbeta4 increases cell surface ATP levels via ATP synthase and have shown further that ATP-responsive P2X4 receptor is required for Tbeta4-induced cell migration PMID: 21106936
30. These data have identified the first transcription factor involved in P2X receptor expression. PMID: 19953327
31. Results show that P2X4 and P2X6 receptors are associated with VE-cadherin at HUVEC adherens junctions. PMID: 12088286
32. shear stress stimulates pulmonary artery endothelial cells to release ATP, which activates Ca2+ influx via P2X4 receptors. PMID: 12714321
33. We have identified a distinct subpopulation of P2X4-positive macrophages infiltrating the dystrophic fibres. These cells were absent from normal muscle and rarely present in the dystrophic muscle taken before and after the onset of degeneration. PMID: 15006691
34. Increased contractility likely underlies survival benefit from P2X4 receptor overexpression. PMID: 15130891
35. in human parotid acinar cells, in addition to modulation of Ca(2+) release, Ca(2+) influx through P2X(4)R may constitute a further locus for the synergistic effects of Ca(2+) and PKA activation. PMID: 15262999
36. wild-type desensitization properties requires an aromatic moiety at position 374 and an amino rather than a guanidino group at position 373 PMID: 16533808
37. P2X4 receptor-specific residues contribute to the ivermectin effects on channel deactivation PMID: 16949036
38. Main role for P2X(4) receptor in nucleotide-induced apoptosis in human mesangial cells, indicating a relevant role for purinergic signaling in regulating death rate in these cells. PMID: 17264311
39. This review discusses the need to reinterpret the assumed "go-it alone" function of the P2X7 receptor in light of convincing biochemical and electrophysiological evidence for the existence of P2X4/P2X7 heteromeric receptors. PMID: 17895406
40. support a common site of ATP action at P2X receptors and suggest that non-conserved residues also play a regulatory role in agonist action PMID: 18487206
41. analysis of molecular shape, architecture, and size of P2X4 receptors PMID: 18635539
42. INF-gamma selectively increases P2X4-receptor gene expression, leading to an up-regulation of purinergic signaling in vascular endothelial cells. PMID: 18678988
43. P2X(4) and P2X(7) receptors are expressed by human osteoblast-like cells. P2X(7) receptor is mainly responsible for pore formation although P2X(4) receptors may also be involved. PMID: 19226284
44. This study presents a picture whereby P2X(4)R become functional in response to initial phagocytic stimuli but return to a non-functional state during sustained activation by classical macrophage activation. PMID: 19283779
45. Results suggest that amyloid beta(1-42)-induced synaptic dysfunction and neuronal death may involve perturbations in P2X4 purinergic receptors. PMID: 19562525

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HGNC: 8535

OMIM: 600846

KEGG: hsa:5025

STRING: 9606.ENSP00000336607

UniGene: Hs.321709