Recombinant Human Pantetheinase(VNN1)

Code CSB-YP025883HU
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Source Yeast
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Code CSB-EP025883HU
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Source E.coli
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Code CSB-EP025883HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP025883HU
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Source Baculovirus
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Code CSB-MP025883HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names VNN1
Uniprot No. O95497
Alternative Names HDLCQ8; High density lipoprotein cholesterol level quantitative trait locus 8, included; Pantetheinase; Pantetheine hydrolase; Tiff66; V-1; Vanin 1; Vanin-1; Vannin 1; Vascular non inflammatory molecule 1; Vascular non-inflammatory molecule 1; VNN 1; VNN1; VNN1_HUMAN
Species Homo sapiens (Human)
Expression Region 22-491
Target Protein Sequence QDTFTAAVY EHAAILPNAT LTPVSREEAL ALMNRNLDIL EGAITSAADQ GAHIIVTPED AIYGWNFNRD SLYPYLEDIP DPEVNWIPCN NRNRFGQTPV QERLSCLAKN NSIYVVANIG DKKPCDTSDP QCPPDGRYQY NTDVVFDSQG KLVARYHKQN LFMGENQFNV PKEPEIVTFN TTFGSFGIFT CFDILFHDPA VTLVKDFHVD TIVFPTAWMN VLPHLSAVEF HSAWAMGMRV NFLASNIHYP SKKMTGSGIY APNSSRAFHY DMKTEEGKLL LSQLDSHPSH SAVVNWTSYA SSIEALSSGN KEFKGTVFFD EFTFVKLTGV AGNYTVCQKD LCCHLSYKMS ENIPNEVYAL GAFDGLHTVE GRYYLQICTL LKCKTTNLNT CGDSAETAST RFEMFSLSGT FGTQYVFPEV LLSENQLAPG EFQVSTDGRL FSLKPTSGPV LTVTLFGRLY EKDWASNASS G
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Gene References into Functions
  1. findings suggest that the metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia PMID: 28576495
  2. Data show that G protein-coupled receptor, family C, group 5, member A protein (GPRC5A) regulates oxidative stress through vanin 1 protein (VNN1). PMID: 28316092
  3. These data suggest that urinary vanin-1 is an early predictive biomarker for decline in eGFR in patients with urothelial carcinoma after dosing of cisplatin PMID: 27317936
  4. serum pantetheinas, encoded by the VNN1 gene, level regulates erythrocyte life span and modulates the risk of developing complicated malaria. PMID: 26343328
  5. VNN1 contributes to corticosteroid responsiveness, and changes in VNN1 nasal epithelial mRNA expression and VNN1 promoter methylation might be clinically useful biomarkers of treatment response in asthmatic children. PMID: 25910714
  6. Our study provides strong biological evidence for the association of the identified SNP with BP and suggests that vanin-1 misfolding and degradation are the underlying molecular mechanism. PMID: 25233454
  7. show that hepatic vanin-1 is under extremely sensitive regulation by PPARalpha and that plasma vanin activity could serve as a readout of changes in PPARalpha activity in human subjects PMID: 24751833
  8. The X-ray crystal structure of human vanin 1 at 2.25 A resolution is presented, which is the first reported structure from the vanin family, as well as a crystal structure of vanin 1 bound to a specific inhibitor. PMID: 25478849
  9. Serum vanin-1 levels may be low in the end-stage renal failure and transiently increase after transplant owing to transient renal function deterioration, which does not lead to elevation of serum creatinine levels in renal transplant patients. PMID: 24702142
  10. Our results suggest that vanin-1 can distinguish between chronic responders and non-responders ITP patients as well as between newly diagnosed ITP patients and healthy controls. PMID: 23534352
  11. Alternative Splicing in VNN1 gene is associated with colorectal cancer. PMID: 24687856
  12. Single-nucleotide polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with inflammatory bowel diseases. PMID: 23949622
  13. Microparticle internalization required the interaction of the ectoenzyme Vanin-1 (VNN1), an abundant surface protein on the microparticles, with lipid raft domains of endothelial cells. PMID: 24106341
  14. It isthe enzyme that recycles pantothenic acid (vitamin B5) generated during coenzyme A breakdown and actively involved in the progression of inflammatory reactions by generating cysteamine. PMID: 23978960
  15. Liver contributes to Vanin-1 secretion in serum and PPARalpha is a limiting factor in serum Vnn1 production. PMID: 24140347
  16. data do not support a major role for the Vanin 1 T26I variant in determining blood pressure level and incident ischemic events PMID: 21550219
  17. Our data suggest that VNN1 gene expression and the G-137T variant are associated with HDL-C levels in Mexican children, particularly in prepubertal girls. PMID: 23185446
  18. Urinary vanin-1, an ectoenzyme pantetheinase, distinguished diabetic patients with macroalbuminuria from those with normal albuminuria. PMID: 21544065
  19. Vanin-1 is a specific and sensitive biomarker for renal tubular injury induced by organic solvents. PMID: 21907259
  20. Overexpression of VNN1, an oxidative stress sensor in epithelial cells, was most strongly associated with progression to chronic immune thrombocytopenia PMID: 21325602
  21. The combination of VNN1 and MMP9 may be used as a novel blood biomarker panel for the discrimination of pancreatic cancer-associated diabetes from type 2 diabetes. PMID: 20571492
  22. Pantetheinase (Vnn1) is critical for the host susceptibility to malaria. PMID: 17312006
  23. missense SNP rs2272996 (or N131S) in the VNN1 gene was significantly associated with hypertension in African Americans and the association was replicated in Mexican Americans; a non-significant opposite association was observed in European Americans PMID: 18043751
  24. vanin-1 and vanin-3 are induced at the mRNA and protein level by psoriasis-associated proinflammatory cytokines (Th17/Th1) but not by Th2 cytokines. PMID: 19322213

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Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor
Protein Families Carbon-nitrogen hydrolase superfamily, BTD/VNN family
Tissue Specificity Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
Database Links

HGNC: 12705

OMIM: 603570

KEGG: hsa:8876

STRING: 9606.ENSP00000356905

UniGene: Hs.12114

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