Recombinant Human Peptidoglycan recognition protein 3 (PGLYRP3)

Code CSB-YP017864HU
MSDS
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Source Yeast
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Code CSB-EP017864HU
MSDS
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Source E.coli
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Code CSB-EP017864HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP017864HU
MSDS
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Source Baculovirus
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Code CSB-MP017864HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PGLYRP3
Uniprot No.
Alternative Names
PGLYRP3; PGRPIA; Peptidoglycan recognition protein 3; Peptidoglycan recognition protein I-alpha; PGLYRPIalpha; PGRP-I-alpha; Peptidoglycan recognition protein intermediate alpha
Species
Homo sapiens (Human)
Expression Region
18-341
Target Protein Sequence
WDT PTIVSRKEWG ARPLACRALL TLPVAYIITD QLPGMQCQQQ SVCSQMLRGL QSHSVYTIGW CDVAYNFLVG DDGRVYEGVG WNIQGLHTQG YNNISLGIAF FGNKIGSSPS PAALSAAEGL ISYAIQKGHL SPRYIQPLLL KEETCLDPQH PVMPRKVCPN IIKRSAWEAR ETHCPKMNLP AKYVIIIHTA GTSCTVSTDC QTVVRNIQSF HMDTRNFCDI GYHFLVGQDG GVYEGVGWHI QGSHTYGFND IALGIAFIGY FVEKPPNAAA LEAAQDLIQC AVVEGYLTPN YLLMGHSDVV NILSPGQALY NIISTWPHFK H
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Gene References into Functions
  1. anti-inflammatory role in intestinal epithelial cells during antibacterial immune response PMID: 22099350
  2. expression of PGlyRP3 can be regulated by dietary factors such as probiotic oligosaccharides; PPARgamma is involved in regulation of expression of PGlyRP3 in intestinal mucosa by dietary components PMID: 21451128
  3. Data are consistent with previous reports of association of psoriasis with genes on 1q21, and suggest a role for Pglyrp3 in skin biology. PMID: 16362825
Subcellular Location
Secreted.
Protein Families
N-acetylmuramoyl-L-alanine amidase 2 family
Tissue Specificity
Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed als
Database Links

HGNC: 30014

OMIM: 608197

KEGG: hsa:114771

STRING: 9606.ENSP00000290722

UniGene: Hs.348266

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