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| Code | CSB-YP018424HU |
| Product Type | Recombinant Protein |
| Size | US$2959 |
| Uniprot No. | P37231 |
| Relevance | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels PDPK1 activates its transcriptional activity independently of its kinase activity |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | Nuclear receptor subfamily 1 group C member 3 |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY |
| Research Area | Transcription |
| Source | Yeast |
| Gene Names | PPARG |
| Protein Names | Recommended name: Peroxisome proliferator-activated receptor gamma Short name= PPAR-gammaAlternative name(s): Nuclear receptor subfamily 1 group C member 3 |
| Expression Region | 1-477aa |
| Tag Info | N-terminal 6xHis-tagged |
| Mol. Weight | 56.3kDa |
| Protein Description | Full Length of Isoform 1 |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). |
| Involvement in disease | Obesity (OBESITY); Lipodystrophy, familial partial, 3 (FPLD3); Glioma 1 (GLM1) |
| Subcellular Location | Nucleus, Cytoplasm |
| Protein Families | Nuclear hormone receptor family, NR1 subfamily |
| Tissue Specificity | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
| Database Links |
HGNC: 9236 OMIM: 137800 KEGG: hsa:5468 STRING: 9606.ENSP00000287820 UniGene: Hs.162646 |
| Pathway |
PPAR signaling pathway
Osteoclast differentiation AMPK signaling |
PPARG Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA018424GA01HU | PPARG Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA018424LB01HU | PPARG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018424LC01HU | PPARG Antibody, FITC conjugated | Human | ELISA |
| CSB-PA018424LD01HU | PPARG Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA216430 | PPARG Antibody | Human,Mouse | ELISA,WB |
| CSB-PA000644 | Phospho-PPARG (S112) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA003839 | PPARG Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA080238 | PPARG Antibody | Human,Mouse,Rat | WB,IHC |
| CSB-PA053064 | PPARG Antibody | Human,Mouse | ELISA,IHC |
PPARG Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA018424LA01HU | PPARG Antibody | Human | ELISA, IHC, IF |
PPARG Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP018424HU | Recombinant Human Peroxisome proliferator-activated receptor gamma(PPARG) | E.coli |
| CSB-BP018424HU CSB-MP018424HU |
Recombinant Human Peroxisome proliferator-activated receptor gamma(PPARG) | Baculovirus Mammalian cell |
PPARG ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08623h | Human Peroxisome Proliferator-activated receptor γ,PPAR-γ ELISA Kit | serum, plasma | 19.5 pg/mL |
Recombinant Human Protein delta homolog 1(DLK1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Integrin alpha-2(ITGA2) ,partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Protein phosphatase 1A(PPM1A)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Calmodulin-like protein 3(CALML3)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Transcription activator BRG1(SMARCA4),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Rat Alpha-2-macroglobulin(A2m),partial
Express system: Yeast
Species: Rattus norvegicus (Rat)
