Recombinant Human Poly (rC)-binding protein 1 (PCBP1)

1. Knockdown of PCBP1 promoted both tumorigenesis and metastatic progression in prostate cancer, suggestive of PCBP1 functioning as a tumor suppressor in normal prostate epithelial cells and potentiates tumor formation by up-regulation of MAPK1 expression. PMID: 30078000
2. PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions. PCBP1 does not bind to such oligoribonucleotides but instead binds firmly to oligoribonucleotides in which two 8-oxoG residues are located nearby. The structure-function relationship of PCBP1 was established with the use of PCBP1 mutant proteins with defective conserved KH domains. PCBP1 operates when RNA is more severely damaged. PMID: 29891675
3. High HNRPE1 expression is associated with pancreatic cancer metastasis. PMID: 28560430
4. UBE4A targets PCBP1 for proteasomal degradation and that UBE4A expression can serve as a novel biomarker in thyroid cancer patients. PMID: 28963376
5. Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases. PMID: 28077174
6. It is reported here that TGF-beta directly regulates alternative splicing of cancer stem cell marker CD44 through a phosphorylated threonine179 of SMAD3-mediated interaction with RNA-binding protein PCBP1. PMID: 27746021
7. our findings suggest that PCBP1 is a molecular marker of oxaliplatin resistance in colorectal cancer PMID: 28076324
8. It was concluded that a novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells. PMID: 28250194
9. TGF-beta signaling through Akt2 induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1), driving epithelial to mesenchymal transition and metastasis. PMID: 27067543
10. The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1, and RBM39 stabilizes or increases U2 snRNP recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation. PMID: 28193846
11. BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 3' C-rich domain. PMID: 28027391
12. Low expression of PCBP1 is associated with lung cancer metastasis. PMID: 27683057
13. miR-7977 in extracellular vesicles may be a critical factor that induces failure of normal hematopoiesis via poly(rC) binding protein 1 suppression in myeloid neoplasms. PMID: 26802051
14. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation PMID: 26880484
15. Inhibin betaA is translationally regulated by TGFbeta via hnRNP E1. PMID: 26096938
16. alphaCP1/ alphaCP2 binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome. PMID: 26896798
17. Suggest that PCBP1 might play an important role in preventing the process of epithelial mesenchymal transformation in NSCLC. PMID: 26261610
18. PCBP1 mutations are recurrent in Burkitt lymphomas and might contribute, in cooperation with other mutations, to its pathogenesis. PMID: 26173642
19. Findings provide mechanistic evidence for HOTAIR overexpression and PCBP1 downregulation in gastric cancer metastasis and their correlation with poor survival. PMID: 25612617
20. Our proteomic profiling and subsequent validation indicate that PCBP1 is central to cancer stem cells enrichment and functionality in prostate cancer. PMID: 25661993
21. PCBP1 is a central player in the molecular mechanism causing EMT in GBC-SD cells after TGF-beta treatment; PCBP1 might serve as a useful biomarker for predicting prognosis of gall bladder cancer metastasis PMID: 24889597
22. hnRNP E1 is a new regulator of protein disulphide isomerase translation in oxLDL-activated vascular endothelial cells. PMID: 25389050
23. A novel mechanism by which POLH expression is controlled by PCBP1 via mRNA stability. PMID: 25268038
24. reduced expression of hnRNP-E1 might be involved with the cervical cancer pathogenesis, with folate playing a role in the natural history of HPV infection PMID: 24848140
25. SchA-FAK-p85 complex subsequently selectively recruited and activated Akt2, not Akt1 PMID: 24819169
26. PCBP1 is a positive regulator involved in regulation of EV71 replication in the host specialized membrane-associated replication complex. PMID: 24489926
27. PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells. PMID: 24843120
28. Poly(rC)-binding protein 1 indirectly regulated MAP2K2, FOS, FST, TP53 and WNT7B through H2AFX. PMID: 22622828
29. PCBP1 regulates p63 expression via mRNA stability. PMID: 23940783
30. High hnRNP-E1 expression is associated with uraemic patients on hemodialysis. PMID: 23439585
31. PCBP1 and -2 form a complex for iron delivery to ferritin, and all PCBPs may share iron chaperone activity. PMID: 23640898
32. a role for PCBP1 in posttranscriptional control pathways that can alter the coding potential and/or levels of expression of subsets of mRNAs in thetranscriptome. PMID: 23629627
33. Down-regulation of poly(rC)-binding protein 1 correlates with the malignant transformation of hydatidiform moles. PMID: 22801034
34. Study on the PCBP1 KH domain recognition of C-rich nucleotides. X-ray diffraction data of PCBP1 were collected to 1.77 Angstrom resolution and the diffraction was consistent with space group P2(1), with unit-cell parameters a = 38.59, b = 111.88, c = 43.42 A, alpha = gamma = 90.0, beta = 93.37 degrees. The unit-cell volume is consistent with the presence of four protein-DNA complexes in the asymmetric unit. PMID: 22102042
35. Our findings unravel a critical role of PCBP1 in regulating MAVS for both fine-tuning the antiviral immunity and preventing inflammation PMID: 22105485
36. In HCC patients, the expression of THAP11 mRNA significantly correlated with PCBP1 mRNA expression. Our results suggest a novel role of THAP11 in CD44 alternative splicing and hepatoma invasion PMID: 22673507
37. hnRNP-E1 as a physiologically relevant, sensitive, cellular sensor of folate deficiency. PMID: 21930702
38. Overall, the results presented here suggest that cellular PCBP2 and PCBP1 antagonize vesiculovirus growth by affecting viral gene expression and highlight the importance of these two cellular proteins in restricting virus infections. PMID: 21752917
39. PCBP1 plays a major role in the dynamic expression of AR in both male and female androgen-responsive cells. PMID: 20519371
40. We characterized PCBP1 as a negative regulator of CD44 variants splicing in HepG2 cells PMID: 20361869
41. Loss of PRL-3 is associated with cancer. PMID: 20609352
42. The binding of HuR, CP1, and CP2 to AR mRNA suggests a role for each of these proteins in the post-transcriptional regulation of AR expression in cancer cells. PMID: 12011088
43. PCBP1, a highly homologous isoform of PCBP2, binds to poliovirus stem-loop I with an affinity similar to that of PCBP2 PMID: 12414943
44. The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including this one. PMID: 12431987
45. HADHB trifunctional enzyme, human renin, and poly(C)-binding protein are novel renin mRNA-binding proteins that target a cis-element in the 3'-UTR of renin mRNA and regulate renin production PMID: 12933794
46. deletion of NLS I from alphaCP1 blocks its nuclear accumulation, whereas NLS I and NLS II must both be inactivated to block nuclear accumulation of alphaCP2 PMID: 14612387
47. The interactions of PTB-1 and PCBP1 with their cognate binding sites on the Bag-1 IRES disrupt many of the RNA-RNA interactions, and this creates a largely unstructured region of approximately 40 nucleotides that could permit ribosome binding. PMID: 15169918
48. Kaposi's sarcoma-associated herpesvirus ORF57 binds to PCBP1 as a functional partner for posttranscriptional regulation and is involved in the regulation of the expression of both cellular and viral genes through IRESs. PMID: 15246275
49. hnRNPE1 is a positive effector of collagen synthesis acting at the post-transcriptional level by interaction with the 3'-untranslated regions (3'-UTRs) of COL1A1, 1A2 mRNAs. PMID: 15514164
50. PCBPs act as a transcription factor and positively regulate mu opioid receptor gene expression in NMB cells PMID: 15933215

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HGNC: 8647

OMIM: 601209

KEGG: hsa:5093

STRING: 9606.ENSP00000305556

UniGene: Hs.2853