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| Code | CSB-YP021799HU |
| Product Type | Recombinant Protein |
| Size | US$2010 |
| Uniprot No. | P51531 |
| Relevance | Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a postmitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth . |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | ATP-dependent helicase SMAR;CA2BRG1-associated factor 190B ;BAF190BProtein brahma homolog |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | SYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAF |
| Research Area | Neuroscience |
| Source | Yeast |
| Gene Names | SMARCA2 |
| Protein Names | Recommended name: Probable global transcription activator SNF2L2 EC= 3.6.4.-Alternative name(s): ATP-dependent helicase SMARCA2 BRG1-associated factor 190B Short name= BAF190B Protein brahma homolog Short name= hBRM SNF2-a |
| Expression Region | 700-1216aa |
| Tag Info | N-terminal 6xHis-tagged |
| Mol. Weight | 61.7kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically |
| Involvement in disease | Nicolaides-Baraitser syndrome (NCBRS); Schizophrenia (SCZD) |
| Subcellular Location | Nucleus |
| Protein Families | SNF2/RAD54 helicase family |
| Database Links |
HGNC: 11098 OMIM: 181500 KEGG: hsa:6595 STRING: 9606.ENSP00000265773 UniGene: Hs.298990 |
SMARCA2 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA021799LA01HU | SMARCA2 Antibody | Human | ELISA, IHC, ChIP |
SMARCA2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA021799LB01HU | SMARCA2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021799LC01HU | SMARCA2 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA021799LD01HU | SMARCA2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA004649 | SMARCA2 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA253060 | SMARCA2 Antibody | Human | ELISA,IHC |
| CSB-PA822578 | SMARCA2 Antibody | Human | ELISA,IHC |
SMARCA2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP021799HU | Recombinant Human Probable global transcription activator SNF2L2(SMARCA2),partial | E.coli |
| CSB-BP021799HU CSB-MP021799HU |
Recombinant Human Probable global transcription activator SNF2L2(SMARCA2) ,partial | Baculovirus Mammalian cell |
Recombinant Human Low-density lipoprotein receptor-related protein 2(LRP2),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Transcriptional coactivator YAP1(YAP1)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Pterin-4-alpha-carbinolamine dehydRatase(PCBD1)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Bovine Muellerian-inhibiting factor(AMH),Yeast
Express system: Yeast
Species: Bos taurus (Bovine)
Recombinant Human Mitogen-activated protein kinase 13(MAPK13)
Express system: E.coli
Species: Homo sapiens (Human)
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