Recombinant Human Proteasome subunit beta type-8 (PSMB8)

1. PSMB8 is closely associated with migration, proliferation, and apoptosis of glioma cells. PMID: 29428669
2. The present study illustrated that the carriage of LMP7 rs2071543-AA and TAP2 rs1800454-AA had a negative effect on treatment response to pegIFN-alpha/RBV among genotype 1 patient with chronic hepatitis C (CHC) in a Chinese Han population PMID: 29039469
3. JAK1 mutations are highly frequent in microsatellite unstable endometrial cancer, not associated with survival, but are associated with impaired upregulation of LMP7 and HLA class I and may therefore facilitate immune escape PMID: 27213585
4. Upregulation of proteasome subunit beta type 8 PSMB8 and PDZ binding kinase PBK was confirmed by real-time reverse transcription-PCR analysis. PMID: 26894977
5. This is the first study to report that the heterozygous LMP2 R/C and homozygous C/C genotypes increase susceptibility to ESCC in the Kazakh population and that the heterozygous LMP7 Q/K genotype decreases susceptibility to ESCC in this population PMID: 29073155
6. PSMB8 rs2071464 was associated with generalized and active vitiligo from Gujarat whereas TAP1 rs1135216 showed no association. The down-regulation of PSMB8 in patients with risk genotype 'CC' advocates the vital role of PSMB8 in the autoimmune basis of vitiligo. PMID: 28700671
7. results suggest that PSMB8 is a predictive marker of preoperative radiosensitivity in locally advanced rectal cancer patients. PMID: 28721901
8. Data show that tight junction protein 1 (TJP1) suppressed expression of the catalytically proteasome subunits LMP7 and LMP2, decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR/JAK1/STAT3 signaling. PMID: 27132469
9. there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients PMID: 27098790
10. We described a Brazilian patient with CANDLE syndrome possessing a novel mutation in the PSMB8 gene. PMID: 26567544
11. designed siRNAs that efficiently silence LMP2, LMP7 and MECL-1 gene expression. PMID: 26944796
12. Proteasome beta5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PMID: 27100179
13. demonstrated that patients with the LMP-7 CA/AA genotypes were more likely to have advanced fibrosis scores than those bearing the CC genotype PMID: 27156327
14. lupus nephritis showed up-regulation of the immunoproteasome subunit LMP7 in tubular epithelial cells associated with type I interferon signature. PMID: 25889472
15. Comparison with reference profiles of sorted immune cells and healthy muscle confirmed upregulation of PSMB8 and -9 in myositis biopsies beyond infiltration related changes. PMID: 25098831
16. The LMP7 gene promoter methylation and protein downregulation were correlated at high extent in Kazakh's ESCC patients, and may explain the epigenetic regulation on gene expression. PMID: 23283737
17. In patients with primary Sjogren's syndrome, the expression of LMP7 (but not LMP2) is up-regulated in the labial gland. PMID: 21529441
18. The MAGE-C(2336-344) antigenic peptide is produced by the immunoproteasome and intermediate proteasome beta1i-beta5i, but not by the standard proteasome nor intermediate proteasome beta5i. PMID: 22925930
19. high risk of colon cancer was associated with LMP7-K/Q genotype and low risk with LMP7-Q/Q genotype; results suggest the presence of LMP7-K can reduce formation of immunoproteasomes and thus peptide processing, followed by reduced peptide-HLA presentation, a crucial factor in the immune response against cancer PMID: 22037870
20. CANDLE syndrome is caused by mutations in PSMB8, a gene recently reported to cause "JMP" syndrome in adults. PMID: 21953331
21. the genetic variant within the LMP2/LMP7 gene would increase the risk of intestinal M. tuberculosis infection. PMID: 21303409
22. found a homozygous missense mutation (G197V) in immunoproteasome subunit, beta type 8 (PSMB8), which encodes one of the beta subunits induced by IFN-gamma in patients from 2 consanguineous families with lipodystrophy PMID: 21881205
23. Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome PMID: 21852578
24. we identified two single nucleotide polymorphisms within the beta5i/LMP7-encoding gene sequences, which were in strong linkage disequilibrium, as independent genetic risk factors for type 1 diabetes development in humans PMID: 21804012
25. HLA-I, TAP1, CNX, LMP7, Erp57, Tapasin and ERAP1 were down-regulated in 68%, 44%, 48%, 40%, 52%, 32% and 20% of esophageal squamous cell carcinoma lesions then, respectively. PMID: 21362330
26. PSMB8 encodes a catalytic subunit of the 20S immunoproteasomes called beta5i. Immunoproteasome-mediated proteolysis generates immunogenic epitopes presented by major histocompatibility complex (MHC) class I molecules PMID: 21129723
27. In a southern Spanish population, no differences were observed in the frequencies of the LMP and TAP genotypes between brucellosis patients and controls. PMID: 20470844
28. The frequencies of LMP7 genotypes and alleles showed no significant differences among different ages of diabetic onset. PMID: 11793848
29. Impaired expression of proteasome subunits is involved in the loss of HLA class I expression in human colon cancer cells. PMID: 12519221
30. LMP7 is associated with vitiligo. PMID: 14551602
31. upregulation by IRF-1 and interferon gamma PMID: 15907481
32. Expression of LMP7E1 is cancer cells is an additional strategy of oncogenesis PMID: 16423992
33. two inducible subunits of the proteasome, lmp2 and lmp7, are transcriptionally up-regulated by heat shock; heat-shocked cells show enhanced presentation of immunoproteasome-dependent MHC I antigenic epitopes, but not immunoproteasome-independent epitopes PMID: 17142736
34. LMP7-145 site is associated with the risk of HBV infection. PMID: 17525827
35. study found strong associations of psoriasis with variant alleles of LMP and TAP PMID: 17581627
36. Patients with proteinuria greater than 0.5 g/1.73 m(2)/day had a significant switch of the chymotryptic-like beta5 protease to the LMP7 subunit, but this did not occur in patients with idiopathic nephrotic syndrome PMID: 19037255
37. The different proteasome profiles of (IFN)DC and (IL-4)DC were associated with a greater ability of (IFN)DC to present an immunodominant epitope that requires LMP7 expression for its processing. PMID: 19065646
38. Downregulation of LMP7 is associated with acute myeloid leukaemic blasts. PMID: 19148137
39. the immunoproteasome appears to be a key link between inflammatory factors and the control of vascular cell apoptosis and may thus be an important factor in plaque rupture and myocardial infarction. PMID: 19443843
40. LMP7 gene polymorphism showed identical frequency of different genotypes in hypertensive patients (Lys/Lys--92.4%, Lys/Gln--7.6%, Gln/Gln--0%) and healthy people (97.3%, 2.7%, 0% correspondingly; P = 0.16). PMID: 19526842
41. the reduced LMP7-mRNA level by HSV-1 could be of biological importance, since the virus could escape/hide from immune system of the host and establish latency processes. PMID: 19619915
42. Interferon-induced PSMB8/LMP7 accelerates the degradation of Mcl-1 and increases the sensitivity of vascular lesion cells to apoptosis induced by fas ligation. PMID: 19443843

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HGNC: 9545

OMIM: 177046

KEGG: hsa:5696

STRING: 9606.ENSP00000364016

UniGene: Hs.180062