Recombinant Human Protein CREG1 (CREG1)

1. Studies demonstrated that CREG may modulate homeostasis of vascular wall cells and inhibit inflammation of vascular tissue cells and macrophages. Mechanistically, CREG behaves like a typical soluble lysosomal protein that regulates the formation and maturation of lysosomes by modulating the small GTPase protein Rab7, to mediate autophagy in vascular vascular tissue cells. [review] PMID: 27784214
2. These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer. PMID: 26722374
3. Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation. PMID: 24896341
4. The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway. PMID: 24018888
5. CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells. PMID: 23580165
6. miR-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation. PMID: 23518389
7. Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. PMID: 23040447
8. Upregulation of CREG expression induced HUVEC migration. PMID: 21939655
9. Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition. PMID: 21263217
10. Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R, modulating SMC phenotypic switching from contractile to proliferative. PMID: 21195083
11. no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population PMID: 20951690
12. CREG plays a key role in modulating VSMC apoptosis through the p38 and JNK signal transduction pathways, both in vitro and in s PMID: 20060003
13. CREG plays a critical role in the inhibition of SMC migration, as well as maintaining SMCs in a mature phenotype PMID: 19769965
14. putative flavin mononucleotide-binding pocket in CREG is sterically blocked by a loop and several key bulky residues PMID: 16344469
15. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. PMID: 18267954
16. We demonstrate that CREG is expressed in the vascular endothelium; data suggests that CREG differentially regulates the growth of the denuded artery wall and smooth vascular muscle cell. PMID: 18472385
17. The expression of CREG improves cardiac functions and inhibits cardiac hypertrophy, inflammation and fibrosis through blocking MEK-ERK1/2-dependent signalling. PMID: 19413895

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HGNC: 2351

KEGG: hsa:8804

STRING: 9606.ENSP00000359540

UniGene: Hs.5710