Recombinant Human Pumilio homolog 1 (PUM1), partial

1. Variants in PUM1 may not contribute to primary ovarian insufficiency in Han Chinese women PMID: 29297114
2. PUM1 SNP is associated with Osteoporosis and Obesity. PMID: 29145611
3. Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion. PMID: 28760986
4. Thus, PUM1 promotes the development and progression of ovarian cancer, which may occur via the above-mentioned molecules. PMID: 29428722
5. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1. PMID: 27157388
6. results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth. PMID: 28232582
7. Pumilios (including PUM1 and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW] PMID: 26517885
8. Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2.Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability. PMID: 26724866
9. PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6. PMID: 25512524
10. The promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs. PMID: 23625657
11. MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo. PMID: 22916034
12. human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs) PMID: 22345517
13. Three distinct modes of target RNA binding by PUM1 around the fifth mRNA base were observed. PMID: 21397187
14. Pumilio-1 (PUM1) is a ubiquitously expressed RBP that was shown to interact with p27-3' UTR. PMID: 20818387
15. The reference genes of choice when performing RT-qPCR on normal and malignant breast specimens should be either the collected group of 3 genes (TBP, RPLP0 and PUM1) employed as an average, or PUM1 as a single gene. PMID: 18211679
16. Description of the structures of hPum Puf domain complexed to two noncognate RNAs, CycB(reverse) and Puf5. PMID: 18328718
17. ribonomic analysis of mRNAs associated with ribonucleoproteins containing an endogenous human PUF protein, Pum1 PMID: 18411299
18. Puf-A transcripts were uniformly distributed in early embryos, but became restricted primarily to eyes and ovaries at a later stage of development PMID: 19319195

Show More

Hide All

HGNC: 14957

OMIM: 607204

KEGG: hsa:9698

STRING: 9606.ENSP00000391723

UniGene: Hs.281707