Recombinant Human Ras-related protein Rab-5C (RAB5C)

Amino acids 1-216 constitute the expression domain of recombinant Human RAB5C. The theoretical molecular weight of the RAB5C protein is 39.5 kDa. Expression of this RAB5C protein is conducted in e.coli. The RAB5C coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant RAB5C protein in following stages of expression and purification.

Ras-related protein Rab-5C (RAB5C) belongs to the Rab family of small GTPases that play crucial roles in regulating intracellular vesicle trafficking and membrane fusion events. Specifically, RAB5C is associated with the early endosomal compartment and is involved in controlling endocytosis, vesicle fusion, and membrane trafficking. The main function of RAB5C is to regulate the dynamics of early endosomes, which are essential for the sorting and processing of internalized cargo. It facilitates the fusion of early endosomes with other vesicles and organelles, contributing to the coordination of cellular transport processes. Research areas related to RAB5C often focus on understanding its role in endocytic pathways, intracellular signaling, and membrane trafficking events. Investigating the molecular mechanisms underlying RAB5C function provides insights into fundamental cellular processes and may have implications for various physiological and pathological conditions, including the regulation of receptor internalization, signal transduction, and membrane homeostasis.