RAB5C Antibody

Datasheet

Code	CSB-PA041280
Size	US$166
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Image	Gel: 10%SDS-PAGE,Lysate: 40 μg,Lane 1-2: A549 cells, Lovo cells,Primary antibody: CSB-PA041280(RAB5C Antibody) at dilution 1/100 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

P51148

Target Names

RAB5C

Alternative Names

L1880 antibody; RAB; member of RAS oncogene family like antibody; RAB5C antibody; RAB5C; member of RAS oncogene family antibody; RAB5C; member RAS oncogene family antibody; RAB5C_HUMAN antibody; RAB5CL antibody; RAB5L antibody; RABL antibody; Ras-related protein Rab-5C antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human RAB5C

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Protein transport. Probably involved in vesicular traffic.

Gene References into Functions

We identify RAB5C as a new candidate gene for type-2 diabetes risk with a functional role in endosomal type-2 diabetes module. Functional analysis shows that RAB5C is tyrosine phosphorylated. Data analysis reveals a tyrosine phosphorylation motif in the GTP binding site of RAB5C which may be targeted by insulin receptor. Insulin-dependent tyrosine phosphorylation of RAB5C is inhibited by overexpression of HACD3 (PTPLAD1). PMID: 30300385
Enforced miR-509 expression in NALM6 cells reduced RAB5C mRNA and protein levels, and RAB5C was demonstrated to be a direct target of miR-509. PMID: 25368993
PLP2 and RAB5C are binding partners of TPD52. PMID: 24604726
Rab5C modulates Rac1-mediated cell motility. PMID: 24587345
GTP-Rab5c also bound to AMAP1, and activation of Rab5c by EGFR signaling was necessary to promote the intracellular association of AMAP1 and PRKD2 PMID: 22734003

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome.

Protein Families

Small GTPase superfamily, Rab family

Database Links

HGNC: 9785

OMIM: 604037

KEGG: hsa:5878

STRING: 9606.ENSP00000345689

UniGene: Hs.650382

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ras signaling pathway Endocytosis Virus Infection

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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