Recombinant Human Secreted phosphoprotein 24(SPP2)

Code CSB-YP615665HU
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Source Yeast
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Code CSB-EP615665HU
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Source E.coli
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Code CSB-EP615665HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP615665HU
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Source Baculovirus
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Code CSB-MP615665HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names SPP2
Uniprot No. Q13103
Alternative Names SPP2; SPP24; Secreted phosphoprotein 24; Spp-24; Secreted phosphoprotein 2
Species Homo sapiens (Human)
Expression Region 30-211
Target Protein Sequence F PVYDYDPSSL RDALSASVVK VNSQSLSPYL FRAFRSSLKR VEVLDENNLV MNLEFSIRET TCRKDSGEDP ATCAFQRDYY VSTAVCRSTV KVSAQQVQGV HARCSWSSST SESYSSEEMI FGDMLGSHKW RNNYLFGLIS DESISEQFYD RSLGIMRRVL PPGNRRYPNH RHRARINTDF E
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Could coordinate an aspect of bone turnover.
Gene References into Functions
  1. Spp24 can inhibit the growth of prostate cancer and its bone metastasis induced by BMP2; spp24 may have great potential to be a therapeutic agent in clinical situations PMID: 27793899
  2. the two mutations of SPP2 have dominant negative effects and cellular accumulation of Spp-24 might be particularly toxic to photoreceptors and/or retinal pigment epithelium. SPP2 has a new role in retinal degeneration. PMID: 26459573
  3. Report describes a C-terminal fragment within SPP24 that is distinct from the cystatin domain and which independently binds to BMP-2 and TGF-beta. This fragment inhibited BMP-2 activity in an ectopic bone forming assay. PMID: 25418420
  4. Spp24, or proteolytic products of Spp24, bind cytokines of the TGF-beta superfamily and also activate intracellular signaling pathways [review] PMID: 25339413
  5. Spp24 truncation products have effects on osteoblastic differentiation mediated by kinase pathways that are independent of exogenous BMP/TGF-beta cytokines. PMID: 25501958
  6. Results describe the localization of the human secreted phosphoprotein 24 gene, its structure and the start of transcription in liver. PMID: 15062857
  7. spp24 contains at least 2 single nucleotide polymorphisms. Given its mechanism of action and sequence variability, SPP24 may be an interesting candidate for future studies of the genetic regulation of bone mass. PMID: 19375587

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Subcellular Location Secreted
Protein Families SPP2 family
Tissue Specificity Detected in liver and plasma.
Database Links

HGNC: 11256

OMIM: 602637

KEGG: hsa:6694

STRING: 9606.ENSP00000168148

UniGene: Hs.444488

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