Recombinant Human Small COPII coat GTPase SAR1B (SAR1B SARA2 SARB)

1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
2. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease PMID: 29540175
3. Report compensatory Sar1a elevation after Sar1b gene deletion in Caco-2/15 cells prevents chylomicron collapse. PMID: 28982670
4. SAR1B polymorphisms were associated with Alzheimer's disease (AD) risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE epsilon4 status offered a better sensitivity for AD screening. PMID: 25703997
5. Our data also suggest that Sar1B overexpression contributes to regulation of CHOL transport and metabolism by facilitating rapid uptake and transport of CHOL. PMID: 25826777
6. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
7. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
8. Sar1b expression may promote intestinal lipid transport with the involvement of the coat protein complex II network and the processing of SREBP-1c. PMID: 21836065
9. Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene. PMID: 19846172
10. identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption PMID: 12692552
11. Sara2 is an important gene in processes involving erythroid cell proliferation and differentiation. PMID: 15943909
12. Five mutations in the SAR1B gene causing Anderson disease. PMID: 17945526
13. muscular as well as cardiac abnormalities that could be related to the reported expression of SARA2 in these tissues PMID: 18786134

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HGNC: 10535

OMIM: 246700

KEGG: hsa:51128

STRING: 9606.ENSP00000385432

UniGene: Hs.432984