Recombinant Human Striatin (STRN)

Code CSB-YP022880HU
MSDS
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Source Yeast
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Code CSB-EP022880HU
MSDS
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Source E.coli
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Code CSB-EP022880HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP022880HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP022880HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
STRN
Uniprot No.
Alternative Names
MGC125642; SG2NA; Striatin; Striatin Calmodulin binding protein ; STRN; STRN_HUMAN
Species
Homo sapiens (Human)
Expression Region
1-780
Target Protein Sequence
MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK YGTELNQGDM KPPSYDSDEG NETEVQPQQN SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS KRVRALLGFS SDVTDREDDK NQDSVVNGTE AEVKETAMIA KSELTDSASV LDNFKFLESA AADFSDEDED DDVDGREKSV IDTSTIVRKK ALPDSGEDRD TKEALKEFDF LVTSEEGDNE SRSAGDGTDW EKEDQCLMPE AWNVDQGVIT KLKEQYKKER KGKKGVKRPN RSKLQDMLAN LRDVDELPSL QPSVGSPSRP SSSRLPEHEI NRADEVEALT FPPSSGKSFI MGADEALESE LGLGELAGLT VANEADSLTY DIANNKDALR KTWNPKFTLR SHFDGIRALA FHPIEPVLIT ASEDHTLKMW NLQKTAPAKK STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGLI QGWNTTNPNI DPYDSYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE VAPALSVFND TKELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRI LTLESNVDTT ANSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH SMVAHLEAVT SLAVDPNGLY LMSGSHDCSI RLWNLESKTC IQEFTAHRKK FEESIHDVAF HPSKCYIASA GADALAKVFV
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.
Gene References into Functions
  1. striatin-associated Salt Sensitive Blood Pressure is associated with normal plasma renin activity and reduced epinephrine levels PMID: 28985281
  2. The prevalence of STRN-ALK kinase fusions were determined in papillary thyroid cancer of an adult population PMID: 29046324
  3. In this review, we summarize the current understanding of the assembly and functions of STRIPAK complexes( striatin-centered multicomponent supramolecular structures containing both kinases and phosphatases), with a special focus on cell signaling and cancer PMID: 26876214
  4. we report 2 cases of renal cell carcinomas harboring a novel STRN-ALK fusion PMID: 26848800
  5. the "multimodulator" scaffold roles of striatins in the initiation and regulation of the formation of various complex particles and structures, are discussed. PMID: 25501894
  6. PP2A/striatin complex modulates microtubule dynamics by regulating MAP2 phosphorylation PMID: 25497017
  7. the rapid, nongenomic mineralocorticoid receptor pathway (mediated via striatin) has a role in modulating the interaction between salt intake and blood pressure. PMID: 25368024
  8. A recurrent STRN/ALK fusion found in thyroid carcinomas. PMID: 24475247
  9. Our data demonstrate that STRN-ALK fusion occurs in a subset of patients with highly aggressive types of thyroid cancer and provide initial evidence suggesting that it may represent a therapeutic target for these patients. PMID: 24613930
  10. Striatin orchestrates the regulation of Mst3 by PP2A. PMID: 21985334
  11. identify striatin as a molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways PMID: 15569929
  12. Taken together, splicing variation of SG2NA might have some critical roles in differentiation and maturation in metazoan cells. PMID: 18571342
  13. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527

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Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine.
Protein Families
WD repeat striatin family
Tissue Specificity
Preferentially expressed in brain.
Database Links

HGNC: 11424

OMIM: 614765

KEGG: hsa:6801

STRING: 9606.ENSP00000263918

UniGene: Hs.127486

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